Evidence map›Paper›PMID 41983818›Full record

ArticleRevista brasileira de epidemiologia = Brazilian journal of epidemiology2026

Factors associated with false-negative results from the rapid molecular test for pulmonary tuberculosis in the state of São Paulo, Brazil.

Alexandre Tadashi Inomata Bruce, Mariana Gaspar Botelho Funari de Faria, Rubia Laine de Paula Andrade, Ricardo Alexandre Arcêncio, Ione Carvalho Pinto, Dulce Gomes, Esron Soares Carvalho Rocha, Manoel Eduardo de Aquino Tavares, Aline Aparecida Monroe

Abstract read
In one paragraph

Article in Revista brasileira de epidemiologia = Brazilian journal of epidemiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Alexandre Tadashi Inomata BruceUniversidade de São Paulo, Ribeirão Preto School of Nursing, Department of Maternal-Child Nursing and Public Health - Ribeirão Preto (SP) Brazil.ORCID http://orcid.org/0000-0002-7008-8023
Mariana Gaspar Botelho Funari de FariaUniversidade de São Paulo, Ribeirão Preto School of Nursing, Department of Maternal-Child Nursing and Public Health - Ribeirão Preto (SP) Brazil.ORCID http://orcid.org/0000-0002-5544-910X
Rubia Laine de Paula AndradeUniversidade de São Paulo, Ribeirão Preto School of Nursing, Department of Maternal-Child Nursing and Public Health - Ribeirão Preto (SP) Brazil.ORCID http://orcid.org/0000-0001-5843-1733
Ricardo Alexandre ArcêncioUniversidade de São Paulo, Ribeirão Preto School of Nursing, Department of Maternal-Child Nursing and Public Health - Ribeirão Preto (SP) Brazil.ORCID http://orcid.org/0000-0003-4792-8714
Ione Carvalho PintoUniversidade de São Paulo, Ribeirão Preto School of Nursing, Department of Maternal-Child Nursing and Public Health - Ribeirão Preto (SP) Brazil.ORCID http://orcid.org/0000-0001-7541-5591
Dulce GomesUniversidade de Évora, School of Science and Technology - Évora, Portugal.ORCID http://orcid.org/0000-0001-8085-1945
Esron Soares Carvalho RochaUniversidade Federal do Amazonas, Manaus School of Nursing- Manaus (AM) Brasil.ORCID http://orcid.org/0000-0002-1011-6053
Manoel Eduardo de Aquino TavaresUniversidade Federal do Amazonas, Manaus School of Nursing- Manaus (AM) Brasil.ORCID http://orcid.org/0009-0004-6481-7287
Aline Aparecida MonroeUniversidade de São Paulo, Ribeirão Preto School of Nursing, Department of Maternal-Child Nursing and Public Health - Ribeirão Preto (SP) Brazil.ORCID http://orcid.org/0000-0003-4073-2735

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo analyze the factors associated with the frequency of false negative results for the RMT-TB test for the diagnosis of pulmonary tuberculosis in the state of São Paulo.

methodsCross-sectional study using pulmonary tuberculosis cases from the state of São Paulo reported in the TB-WEB system between 2014 and 2023. RMT-TB results were compared with sputum smear microscopy, sputum culture, and sensitivity testing. Subsequently, variables with p<0.05 in the statistical tests were included in the logistic regression.

resultsThere was a significant increase in the use of RMT-TB over the years, reaching 76% of cases in 2023. Analysis of the test accuracy revealed high agreement with sputum culture (82.6%) and the sensitivity test (98.4%), although it showed lower agreement with sputum smear microscopy (78.5%). The study identified factors associated with false-negative results on the RMT-TB, such as advanced age, female sex, HIV status, imprisoned, and a normal chest X-ray. Logistic regression confirmed that these factors increase the likelihood of false-negative results.

conclusionThe RMT-TB is an effective tool for diagnosing pulmonary tuberculosis, but the interpretation of results must consider each patient's specific risk factors, especially in high-risk populations. The study highlights the importance of combining the RMT-TB with other diagnostic methods and clinical evaluation to ensure accurate diagnosis and appropriate treatment.

Indexed as

Mycobacterium tuberculosisTuberculosis, PulmonaryAdultBacilloscopyBrazilCross-Sectional StudiesFalse Negative ReactionsFemaleHumansLogistic ModelsMaleMiddle AgedRapid Diagnostic TestsSensitivity and SpecificitySputum

Identifiers

PMID41983818
PMCPMC13078832

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.