Evidence map›Paper›PMID 41983768›Full record

ArticleJournal of virology2026

Febrifugine dihydrochloride restricts porcine epidemic diarrhea virus replication by modulating the IGF1R-driven PI3K/AKT-apoptosis axis.

Ping Yan, Zin Oo Kyaw, Xiaobing Wang, Nan Li, Yulan Xu, Song Gao, Changchao Huan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ping Yan *Institute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Zin Oo Kyaw *Institute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Xiaobing Wang *Institute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Nan LiInstitute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Yulan XuInstitute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.
Song GaoInstitute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.ORCID 0000-0002-4814-2353
Changchao HuanInstitute of Agricultural Science and Technology Development, College of Veterinary Medicine, Yangzhou University, Yangzhou, China.ORCID 0000-0002-9904-8893

Funding

111 Project D18007China Postdoctoral Science Foundation 2018M632399Jiangsu Provincial Natural Science Fund for Excellent Young BK20220114National Natural Science Foundation of China 32273015Priority Academic Program Development of Jiangsu Higher Education Institutions
6 · The paper itself

Abstract

Porcine epidemic diarrhea (PED) is an acute and highly contagious enteric disease caused by porcine epidemic diarrhea virus (PEDV). The disease poses a significant threat to global swine production, underscoring the urgent need for effective antiviral therapeutics. In this study, we investigated the antiviral activity and underlying mechanism of febrifugine dihydrochloride (FFG), a quinazolinone alkaloid derived from

Indexed as

Antiviral AgentsApoptosisCoronavirus InfectionsPhosphatidylinositol 3-KinasesPorcine epidemic diarrhea virusProto-Oncogene Proteins c-aktQuinazolinesReceptor, IGF Type 1Virus ReplicationAnimalsChlorocebus aethiopsPiperidinesSignal TransductionSwineVero CellsAntiviral AgentsfebrifuginePhosphatidylinositol 3-KinasesPiperidinesProto-Oncogene Proteins c-aktQuinazolinesReceptor, IGF Type 1apoptosisbroad-spectrum antiviral activityfebrifugine dihydrochlorideIGF1RPEDVPI3K/AKT

Identifiers

PMID41983768
PMCPMC13185639

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.