ArticleJournal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine2026
Sweep and Scrutinize: Improving Prostate Cancer Diagnostic Efficacy by Combining Whole-Gland Contrast-Enhanced Transrectal Ultrasound With Fixed-Plane Flash-Replenishment Imaging.
Article in Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo evaluate whether the addition of whole-gland contrast-enhanced transrectal ultrasound (CETRUS) and fixed-plane flash-replenishment imaging (FRI) to conventional transrectal ultrasound (TRUS) improves the diagnostic efficacy of prostate cancer (PCa) in patients with prostate-specific antigen (PSA) levels of 4.00-20.00 ng/mL.
methodsA total of 163 patients scheduled for TRUS-guided biopsy due to elevated PSA (4.00-20.00 ng/mL) were enrolled. Each patient underwent conventional TRUS, whole-gland CETRUS, and FRI before biopsy. Detection rates and diagnostic efficacy for PCa were compared among 3 imaging strategies: conventional TRUS alone, the combination of conventional TRUS with whole-gland CETRUS, and the triple combination.
resultsPCa was diagnosed in 62 of 163 (38.04%), including 29 (46.77%) clinically significant cases. The detection rates were 43.56% for conventional TRUS, 57.06% for conventional TRUS combined with whole-gland CETRUS, and 61.35% for the triple combination. Only 5 clinically insignificant cases were missed by the combined approach. The triple combination demonstrated the highest area under the ROC curve (AUC = 0.747), significantly outperforming conventional TRUS (AUC = 0.669, p = .018) and TRUS with whole-gland CETRUS (AUC = 0.703, p = .026). The combined method also identified significantly more positive biopsy cores (p-
conclusionThe triple-modality combination significantly improves PCa detection rate and diagnostic efficacy in patients with PSA levels of 4.00-20.00 ng/mL, offering a valuable alternative when magnetic resonance imaging is contraindicated or unavailable.
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