Evidence map›Paper›PMID 41983544›Full record

ReviewInternational journal of immunogenetics2026

Don't Cut the Cord: Why Umbilical Cord Blood Still Deserves a Place in Transplantation.

Jenna Nunn, Kay Poulton, Robert Wynn

Abstract readReview
In one paragraph

Review in International journal of immunogenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jenna NunnDepartment of Paediatric Haematology and Bone Marrow Transplant, Manchester University, NHS Foundation Trust, Manchester, UK.ORCID https://orcid.org/0000-0002-7790-9955
Kay PoultonTransplantation Laboratory, Manchester University NHS Foundation Trust, Manchester, UK.
Robert WynnDepartment of Paediatric Haematology and Bone Marrow Transplant, Manchester University, NHS Foundation Trust, Manchester, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The use of umbilical cord blood (UCB) as a stem cell source in haematopoietic stem cell transplant (HSCT) has greatly declined in recent years. It has largely been replaced by mismatched unrelated and family donors, facilitated by advances in transplant technologies, including post-transplant cyclophosphamide to prevent graft-versus-host disease (GVHD). UCB remains a distinctive source of haematopoietic stem cells (HSCs) with unique immunologic and practical advantages, including for those with malignant and non-malignant diseases. Compared to other cell sources, UCB transplantation (UCBT) offers comparable survival with reduced chronic GVHD (cGVHD) and with a potent graft-versus-leukaemia (GVL) effect. These outcomes likely reflect the biology of cord-derived lymphocytes-particularly naïve, adaptable CD8

Indexed as

Cord Blood Stem Cell TransplantationFetal BloodHematologic NeoplasmsHematopoietic Stem Cell TransplantationGraft vs Host DiseaseGraft vs Tumor EffectHumanscord bloodgraft‐versus‐host diseaseleukaemiarelapse bone marrow transplantT‐lymphocytes

Identifiers

PMID41983544
PMCPMC13136670

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.