ArticleThe Journal of organic chemistry2026
Arylation of Olefins with N-Unprotected Bromobisindole Ethanamines: Expanding the Scope of the Mizoroki-Heck Reaction.
Article in The Journal of organic chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A protecting-group-free Mizoroki-Heck arylation of olefins with N-unprotected bromobisindole ethanamines and, more generally, N-unprotected heterocyclic electrophiles is described. Efficient palladium-catalyzed coupling is achieved through appropriate base selection: CsF is optimal for substrates bearing intrinsic basic sites, whereas 1-decylamine is required. The method tolerates a wide range of styrenes, heteroaryl olefins, acrylates, and N-containing substrates, including unprotected tryptamines, anilines, and haloindole derivatives. Its practicality is also demonstrated by the synthesis of the natural product
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