ArticleBioMed research international2026
Assessment of Healing Potential of Alginate and Chitosan-Based Biomaterials for Cranial Bone Defects in Experimental Model.
Article in BioMed research international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Assessment of Healing Potential of Alginate and Chitosan-Based Biomaterials for Cranial Bone Defects in Experimental Model.BioMed research international · 2026Article
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4 authors.
Funding
Abstract
The healing of bone defects in the skull vault is a serious clinical problem. The aim of this study is to evaluate the effect of two osteoplastic materials on the healing of a cranial vault experimental defect by computed tomography. Two material systems are analyzed in detail: (i) a sodium alginate-based matrix modified with hydroxyapatite microparticles and zinc ions and (ii) a chitosan-based matrix containing in situ-formed brushite nanoparticles; both sample types were loaded with cholecalciferol (VitD3). A total of 36 rats aged 6 months showed that the alginate-based biomaterial promotes complete healing of the parietal bone defect after 200 days, whereas healing with the chitosan-based biomaterials at that time was not complete. The second objective was to determine the kinetics of VitD3 release from experimental biocomposites using high-performance liquid chromatography. The kinetics of VitD3 release depends on the material's composition: The composite with chitosan prolongs the drug release to 48 h without the so-called "burst release." In the case of the alginate composite, a "burst release" of vitamin D3 is observed during the first 4 h. Both osteoplastic materials show the potential to optimize reparative osteogenesis in an experimental defect of the flat skull bone, although the regenerative potential of the alginate-based biomaterial is higher.
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