Evidence map›Paper›PMID 41983360›Full record

ArticleInternational journal of fertility & sterility2026

The Effect of Curcumin on Angiogenic and Proliferative Factors inHuman Endometriotic Cells.

Sedigheh Kamrani, Reyhaneh Sadat Hayaei Tehrani, Fereshteh Esfandiari, Firouzeh Ghaffari, Elham Amirchaghmaghi, Kamran Ghaedi, Maryam Shahhoseini

Abstract read
In one paragraph

Article in International journal of fertility & sterility, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sedigheh KamraniDepartment of Cell, Molecular Biology and Microbiology, Faculty of Biological Sciences and Technology, University of Isfahan, Isfahan, Iran.
Reyhaneh Sadat Hayaei TehraniDepartment of Stem Cells and Developmental Biology, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Fereshteh EsfandiariDepartment of Stem Cells and Developmental Biology, Cell Science Research Centre, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran.
Firouzeh GhaffariDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Centre, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Elham AmirchaghmaghiDepartment of Endocrinology and Female Infertility, Reproductive Biomedicine Research Centre, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran.
Kamran GhaediDepartment of Cell, Molecular Biology and Microbiology, Faculty of Biological Sciences and Technology, University of Isfahan, Isfahan, Iran. Email: kamranghaedi@sci.ui.ac.ir.
Maryam ShahhoseiniDepartment of Genetics, Reproductive Biomedicine Research Centre, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran. Email: m.shahhoseini@royan-rc.ac.ir.ORCID 0000-0002-9021-6408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Endometriosis is a benign gynaecological disorder characterised by the presence of endometrial-like tissue outside the uterus. Proliferation of endometrial tissue and neoangiogenesis are essential factors in the development of endometriosis. Vascular endothelial growth factor ( Materials and Methods: In this experimental study, human normal endometrial stromal cells (N-ESCs) from healthy endometrial tissue and human eutopic endometrial stromal cells (EU-ESCs) from endometriosis patients were cultured and treated with different concentrations of curcumin (0-100 mM) for 72 hours. Then, the effects of curcumin on cell viability, proliferation, and migration were assessed using methylthiazole tetrazolium (MTT) and the scratch test, respectively. Expressions of genes involved in angiogenesis ( Results: Curcumin decreased cell migration and proliferation of endometriotic stromal cells in a time- and concentration- dependent manner. It also reduced Conclusion: The anti-migration effect of curcumin on EU-ESCs and its impact on the expression of proliferative and angiogenic genes indicate that curcumin can be a promising treatment for endometriosis.

Indexed as

curcuminEndometriosisH19Insulin-Like Growth Factorsvascular endothelial growth factor

Identifiers

PMID41983360
PMCPMC13080706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.