ArticleAnatolian journal of cardiology2026
Association Between Systemic Immune-Inflammation Index and Cardiac Resynchronization Therapy Response in Patients with Heart Failure.
Article in Anatolian journal of cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac resynchronization therapy (CRT) is an established treatment for selected patients with heart failure (HF); however, a substantial proportion of patients do not derive clinical or echocardiographic benefit. Systemic inflammation has been implicated in adverse myocardial remodeling and may influence response to CRT. This study aimed to evaluate the association between the systemic immune-inflammation index (SII) and CRT response.
methodsThis retrospective, single-center study included 110 patients with HF who underwent CRT implantation. Clinical, echocardiographic, and laboratory parameters, including SII, were assessed at baseline and at 6-month follow-up. Cardiac resynchronization therapy response was defined using combined echocardiographic and clinical criteria. Associations between inflammatory markers and CRT response were analyzed.
resultsNonresponders demonstrated significantly higher baseline SII levels compared with responders. During follow-up, SII values increased significantly in nonresponders, whereas no significant change was observed in responders. Baseline C-reactive protein (CRP) levels were similar between groups. Chronic ischemic heart disease and elevated baseline SII were independently associated with CRT nonresponse. The discriminatory ability of baseline SII for CRT nonresponse was moderate.
conclusionElevated SII was associated with an increased likelihood of CRT nonresponse and persistent inflammatory activity during follow-up. These findings suggest that SII reflects an unfavorable inflammatory and biological milieu related to impaired CRT response, rather than a direct causal mechanism. Systemic immune-inflammation index may serve as a complementary biomarker for risk stratification in patients undergoing CRT.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.