Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
34 authors.
Jonathan Chacon-BarahonaDepartment of Systems and Computational Biomedicine (J.C.-B., J.K.), Weill Cornell Medical College, New York, NY.ORCID 0009-0008-9309-8292
Samuel J ChungDivision of Pulmonary and Critical Care Medicine (S.J.C., A.C.R.), Weill Cornell Medical College, New York, NY.ORCID 0000-0002-5518-7955
Jonah D GarryDivision of Cardiovascular Medicine (J.D.G., E.L.B.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-9140-1632
Franz RischardDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, The University of Arizona, Tucson (F.R.).
Paul M HassounDivision of Pulmonary and Critical Care Medicine (P.M.H., S.C.M., C.E.S.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0003-0601-4975
Stephen C MathaiDivision of Pulmonary and Critical Care Medicine (P.M.H., S.C.M., C.E.S.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0003-3188-7209
Catherine E SimpsonDivision of Pulmonary and Critical Care Medicine (P.M.H., S.C.M., C.E.S.), Johns Hopkins University, Baltimore, MD.ORCID 0000-0002-2388-5660
Gerald BeckDepartment of Quantitative Health Sciences (G.B., J.B.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0002-8876-5045
Nicholas S HillDivision of Pulmonary, Critical Care, and Sleep Medicine, Tufts Medical Center, Boston, MA (N.S.H.).ORCID 0000-0002-8242-8339
Jane A LeopoldDivision of Cardiovascular Medicine (J.A.L.), Brigham and Women's Hospital, Boston, MA.ORCID 0000-0003-0598-8882
Aaron B WaxmanDivision of Pulmonary and Critical Care Medicine (A.B.W.), Brigham and Women's Hospital, Boston, MA.ORCID 0000-0001-7797-0361
Erika B RosenzweigDivision of Pediatrics, New York Medical College, Valhalla (E.B.R.).ORCID 0000-0003-4849-214X
Rebecca R VanderpoolDavis Heart and Lung Research Institute, The Ohio State University, Columbus (R.R.V.).ORCID 0000-0001-6038-0568
Miriam JacobDepartment of Cardiovascular Medicine (M.J., M.M.P., J.E.F., D.H.K., C.L.J.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0002-2529-7467
Reena MehraDivision of Pulmonary, Critical Care and Sleep Medicine, University of Washington Medical Center, Seattle (R.M.).ORCID 0000-0002-6222-2675
Margaret M ParkDepartment of Cardiovascular Medicine (M.J., M.M.P., J.E.F., D.H.K., C.L.J.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0003-4074-8630
J Emanuel FinetDepartment of Cardiovascular Medicine (M.J., M.M.P., J.E.F., D.H.K., C.L.J.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0002-0156-6757
Samar FarhaDepartment of Pulmonary Medicine (S.F.), Cleveland Clinic, Cleveland, OH.
Gabriele GrunigDepartment of Medicine, New York University Grossman School of Medicine (G.G.).
Deborah H KwanDepartment of Cardiovascular Medicine (M.J., M.M.P., J.E.F., D.H.K., C.L.J.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0003-2191-4111
Suzy ComhairLerner Research Institute (S.C.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0003-1918-9002
Serpil ErzurumDepartment of Inflammation and Immunity (S.E.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0001-5202-9065
John BarnardDepartment of Quantitative Health Sciences (G.B., J.B.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0003-2403-8268
Bo HuDepartment of Biostatistics and Bioinformatics, Duke University, Durham, NC (B.H.).ORCID 0000-0003-0606-7639
Christine L JellisDepartment of Cardiovascular Medicine (M.J., M.M.P., J.E.F., D.H.K., C.L.J.), Cleveland Clinic, Cleveland, OH.ORCID 0000-0002-8610-0533
Alexandra C RacanelliDivision of Pulmonary and Critical Care Medicine (S.J.C., A.C.R.), Weill Cornell Medical College, New York, NY.
Jan KrumsiekDepartment of Systems and Computational Biomedicine (J.C.-B., J.K.), Weill Cornell Medical College, New York, NY.ORCID 0000-0003-4734-3791
Evan L BrittainDivision of Cardiovascular Medicine (J.D.G., E.L.B.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0001-5843-3392
Anna R HemnesDivision of Allergy, Pulmonary, and Critical Care Medicine (A.R.H.), Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0002-2755-5845
Evelyn M HornDivision of Cardiology (E.M.H.), Weill Cornell Medical College, New York, NY.ORCID 0000-0002-5751-9415
PVDOMICS Study Group
Funding
Pulmonary Vascular Disease Phenomics Program (PVDOMICS) Data Coordinating CenterU01HL125177 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BECK, GERALD J, ERZURUM, SERPIL C. · 2014 to 2020
$20.0M
Clinical and Translational Training Program in Pulmonary MedicineT32HL087738 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Lorraine B Ware · 2007 to 2026
$7.0M
Multidisciplinary Approach Training in Respiratory ResearchT32HL134629 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI Robert J Kaner, Heather Winona Stout Delgado · 2018 to 2026
$5.2M
Clinical and Mechanistic Understanding of Right Ventricular Steatosis in Pulmonary Arterial HypertensionR01HL155278 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Evan L Brittain · 2022 to 2026
$3.8M
Effect of PDE5 Inhibition on Adipose Metabolism in HumansR01DK124845 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRITTAIN, EVAN L, DAMON, BRUCE M. · 2021 to 2025
$3.4M
Clinical, Genetic, and Proteomic Risk Factors for Pulmonary Hypertension in Heart FailureR01HL146588 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BRITTAIN, EVAN L, FREIBERG, MATTHEW S · 2019 to 2022
$3.4M
Network Medicine and Systems Pharmacology to Advance Precision Medicine in Combined Pulmonary HypertensionR01HL163960 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Evan L Brittain, Anna R Hemnes · 2022 to 2026
$3.4M
Early Detection of Right Ventricular Dysfunction and Emerging Pulmonary Hypertension in Systemic SclerosisR01HL162851 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Monica Mukherjee · 2023 to 2026
$2.5M
Intergrated Endothelial Phenotyping to Redefine Pulmonary HypertensionU01HL125215 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI LEOPOLD, JANE A, WAXMAN, AARON B · 2014 to 2018
$1.7M
PVDOMICS Defining the Future Fingerprints of Pulmonary Vascular DiseaseU01HL125218 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BERMAN-ROSENZWEIG, ERIKA S., HORN, EVELYN · 2014 to 2018
$1.6M
Redefining Pulmonary Hypertension through Pulmonary Vascular Disease Phenomics: Clinical Centers (CC) (U01).U01HL125205 · NHLBI · MAYO CLINIC ROCHESTER · PI FRANTZ, ROBERT PAUL · 2014 to 2018
$1.5M
A molecular phenotype of combined pulmonary hypertensionU01HL125212 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HEMNES, ANNA R, NEWMAN, JOHN HUGHES · 2014 to 2018
backgroundThe metabolic mechanisms underlying right ventricular (RV) dysfunction are poorly understood, particularly outside of group 1 pulmonary hypertension (PH). We aimed to identify metabolites and pathways associated with RV systolic function and explored whether associations differed by pulmonary vascular resistance, PH group 1 status, and sex.
methodsWe analyzed data from the multicenter PVDOMICS (Pulmonary Vascular Disease Phenomics) cohort. RV systolic function metrics included fractional area change (echo), global longitudinal strain (echo), and ejection fraction (cardiac magnetic resonance). We used linear regression adjusted for age, sex, body mass index, and PH group to assess associations between metabolites and RV function. Pathway enrichment analyses were used to identify pathways significantly associated with RV function. Interaction terms were assessed to determine whether metabolite associations were modified by pulmonary vascular resistance, group 1 PH status, or sex. Least absolute shrinkage and selection operator regression was used to develop metabolite-based scores for RV function, and prognostic performance was assessed.
resultsThere were 979 participants with plasma metabolomics and RV function data. Linear regression identified 170 metabolites that were significantly associated with all 3 RV metrics. Androgenic steroid, gamma-glutamyl amino acid, polyamine, vitamin A, fatty acid, and sterol pathways are most strongly associated with RV systolic function. Two metabolites interacted with group 1 PH status, and 6 interacted with pulmonary vascular resistance. Four androgenic steroids are associated more strongly with RV systolic function in women compared with men. Metabolite-based scores were prognostically equivalent to RV systolic function metrics and less accurate than REVEAL Lite 2 scores.
conclusionsWe provide a blueprint of metabolites and metabolic pathways associated with RV systolic function across the spectrum of PH. Novel links to vitamin A and glutathione metabolites were observed. We detected few metabolites that associated with RV systolic function differentially by group 1 PH status or degree of pulmonary vascular resistance elevation. Androgenic steroids may associate more strongly with RV systolic function in women compared with men.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Metabolomics of Right Ventricular Function in Pulmonary Hypertension. · full record | OpenQuestion