In one paragraphArticle in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
23 authors.
R Noah PerryDepartment of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville.ORCID 0000-0002-3555-0964 Graham LenertDepartment of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville.ORCID 0009-0007-9532-898X Ernest Diez BenaventeLaboratory of Experimental Cardiology (E.D.B., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0002-4313-4290 Aydin BölükA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.).
Rebecca HernandezDepartment of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.
Lijiang MaDepartment of Genetics and Genomic Sciences, Institute of Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York, NY (L. Ma).
Nicolas BarberaDepartment of Genome Sciences (R.N.P., N.B., K.W.), University of Virginia, Charlottesville.
Kelsey WattsDepartment of Biomedical Engineering (R.N.P., G.L., K.W.), University of Virginia, Charlottesville.
Victor D MendozaDepartment of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.ORCID 0009-0007-4893-7619 Tiit ÖrdA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.).
Mari TaipaleA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.).ORCID 0000-0001-6805-4599 Nadja SachsDepartment of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel).ORCID 0000-0001-8031-017X Jessica PauliDepartment of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel).ORCID 0000-0001-5984-3529 Michal MokryCentral Diagnostic Laboratory (M. Mokry), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0002-5298-4852 Dominique P V de KleijnDepartment of Vascular Surgery (D.P.V.d.K.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0003-2714-2140 Menno P J de WintherDepartment of Medical Biochemistry, Experimental Vascular Biology, Atherosclerosis and Ischemic Syndromes, Amsterdam Cardiovascular Sciences, Amsterdam Institute for Immunology and Infectious Diseases, Amsterdam University Medical Center, University of Amsterdam, the Netherlands (M.P.J.d.W.).ORCID 0000-0002-4038-6636 Lars MaegdefesselDepartment of Vascular and Endovascular Surgery, Klinikum Rechts der Isar, Technical University of Munich, Germany (N.S., J.P., L. Maegdefessel).ORCID 0000-0001-5228-2634 Karen ReueDepartment of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.ORCID 0000-0002-7487-2624 Minna U KaikkonenA. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio (A.B., T.O., M.T., M.U.K.).ORCID 0000-0001-6294-0979 Johan L M BjörkegrenDepartment of Medicine, Karolinska Institutet, Karolinska Universitetssjukhuset, Huddinge, Sweden (J.L.M.B.).ORCID 0000-0003-1945-7425 Hester M den RuijterLaboratory of Experimental Cardiology (E.D.B., H.M.d.R.), University Medical Center Utrecht, Utrecht University, the Netherlands.ORCID 0000-0001-9762-014X Mete CivelekDepartment of Human Genetics (R.H., V.D.M., K.R., M.C.), University of California, Los Angeles.ORCID 0000-0002-8141-0284 Funding
The impact of estrogen receptor alpha on cardiomyocellular metabolism and healthU54HL170326 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Hooman Allayee · 2023 to 2026
$7.5MMultimodal genetic regulatory architecture of coronary artery diseaseR01HL148239 · NHLBI · UNIVERSITY OF VIRGINIA · PI Clint L Miller · 2019 to 2026
$4.2MIntegrative genomic and functional genomic studies to connect variant to function for CAD GWAS lociR01HL168174 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Wei Li, EDOARDO MARCORA · 2023 to 2026
$3.1MUnderstanding the Molecular Mechanisms of Fibromuscular DysplasiaR01HL148167 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI KADIAN-DODOV, DANIELLA, KOVACIC, JASON CIRIL · 2020 to 2023
$2.8MSystems Genetics of Vascular Smooth Muscle PhenotypesR01HL166428 · NHLBI · UNIVERSITY OF VIRGINIA · PI Mete Civelek · 2023 to 2026
$2.4MFunctional genomics investigation of pleiotropic vascular disease lociR01HL164577 · NHLBI · UNIVERSITY OF VIRGINIA · PI MILLER, CLINT L · 2022 to 2025
$2.3MInterdisciplinary Training Program in Metabolism (UCLA-ITPM)T32DK138892 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Andrea L Hevener, Tamer Sallam · 2025 to 2026
$911kFunctional Characterization of Coronary Artery Disease LociR21HL135230 · NHLBI · UNIVERSITY OF VIRGINIA · PI CIVELEK, METE, GUERTIN, MICHAEL JOSEPH · 2018 to 2019
$242kThe role of nitrogen metabolism in smooth muscle cell phenotypic plasticityF31HL165772 · NHLBI · UNIVERSITY OF VIRGINIA · PI PERRY, ROBERT NOAH · 2022 to 2025
$120kNHLBI NIH HHS F31 HL165772NHLBI NIH HHS R01 HL148167NHLBI NIH HHS R01 HL148239NHLBI NIH HHS R01 HL164577NHLBI NIH HHS R01 HL166428NHLBI NIH HHS R01 HL168174NHLBI NIH HHS R21 HL135230NHLBI NIH HHS U54 HL170326NIDDK NIH HHS T32 DK138892
6 · The paper itselfAbstract
backgroundAtherosclerosis, an inflammatory driver of coronary artery disease, manifests as unstable atheromatous plaques and stable fibrous plaques. Although atheromatous plaques have been extensively studied, fibrous plaques, particularly in women aged <50 years, where erosion contributes significantly to coronary thrombosis, remain less understood. The molecular mechanisms underlying sex differences in plaque biology, including vascular smooth muscle cell contributions, are incompletely defined.
methodsSex-specific gene regulatory networks (GRNs) were constructed from RNA-sequencing data of cultured human vascular smooth muscle cells isolated from 119 male and 32 female heart transplant donors. Network preservation analyses identified female-biased GRNs, which were evaluated in single-cell RNA-sequencing data sets from human carotid atherosclerotic plaques. Bayesian network modeling and proteomic analyses were used to identify and validate regulatory drivers.
resultsTwo female-biased vascular smooth muscle cell networks, GRN
conclusionsThese findings identify MYH9 as a regulator of female-biased fibrous plaque biology and highlight the importance of sex-specific network regulation in atherosclerosis.
Indexed as
Gene Regulatory NetworksMuscle, Smooth, VascularMyocytes, Smooth MuscleMyosin Heavy ChainsPlaque, AtheroscleroticCells, CulturedFemaleFibrosisHumansMaleMiddle AgedPhenotypeProteomicsSex FactorsMYH9 protein, humanMyosin Heavy Chains
Identifiers
PMID41983287
PMCPMC13132102
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390