ArticleHepatobiliary surgery and nutrition2026
Liver transplantation for hepatocellular carcinoma arising in non-cirrhotic liver: a national-wide retrospective cohort study with propensity score matching analysis in China.
Article in Hepatobiliary surgery and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The majority of liver transplantation (LT) recipients for hepatocellular carcinoma (HCC) present with concomitant liver cirrhosis. However, there is limited research focusing on recipients without cirrhosis. This study aims to investigate the prognosis of non-cirrhotic HCC recipients, with the objective of providing a theoretical basis for improving outcomes in this patient population. Methods: This retrospective study analyze outcomes between adult HCC recipients arising in non-cirrhotic and cirrhotic liver based on the China Liver Transplant Registry (CLTR) database from January 2015 to December 2020. Based on important variables, 1:2 propensity score matching (PSM) was performed respectively. Results: A total of 845 non-cirrhotic HCC recipients were enrolled, which were matched with cirrhotic HCC recipients (n=1,690) at a 1:2 ratio from CLTR. Compared with cirrhotic recipients, non-cirrhotic recipients presented lower overall (P=0.003), tumor free (P=0.03) and graft survival rates (P=0.007). Among recipients fulfilling Hangzhou criteria, the above survival rates of non-cirrhotic recipients were lower than those of cirrhotic recipients (P=0.001, P=0.02 and P=0.002, respectively). The HCC recurrence rate was higher in cirrhotic recipients than that in non-cirrhotic recipients (15.3% Conclusions: LT for non-cirrhotic HCC is associated with a poor prognosis. This finding suggests that non-cirrhotic HCC may exhibit more aggressive characteristics and warrants greater clinical attention.
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