Evidence map›Paper›PMID 41983138›Full record

ArticleFrontiers in immunology2026

Plantaricin BM-1 enhances anti-colorectal cancer effects by inhibiting CD8+ cytotoxic T cell apoptosis via the ERK/AP1/Bim signaling pathway.

Xuan Zheng, Qi Wang, Xiaodong Song, Jingxin Zhu, Chunyu Dai, Junhua Jin, Congyang Cheng, Hongxing Zhang, Yuanhong Xie

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Xuan Zheng *Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Qi Wang *Beijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Xiaodong SongKey Laboratory of Dairy Quality Digital Intelligence Monitoring Technology, State Administration for Market Regulation, Inner Mongolia Mengniu Dairy (Group) Co., Ltd., Hohhot, Inner Mongolia, China.
Jingxin ZhuBeijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Chunyu DaiBeijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Junhua JinBeijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Congyang ChengKey Laboratory of Dairy Quality Digital Intelligence Monitoring Technology, State Administration for Market Regulation, Inner Mongolia Mengniu Dairy (Group) Co., Ltd., Hohhot, Inner Mongolia, China.
Hongxing ZhangBeijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.
Yuanhong XieBeijing Laboratory of Food Quality and Safety, Beijing Key Laboratory of Agricultural Product Detection and Control of Spoilage Organisms and Pesticide Residue, College of Food Science and Engineering, Beijing University of Agriculture, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality. Plantaricin BM-1, a class IIa bacteriocin from Lactobacillus plantarum, exhibits anticancer potential, but its Methods: Using an AOM/DSS-induced CRC mouse model, we administered Plantaricin BM-1 orally and evaluated therapeutic effects via phenotypic, pathological, and inflammatory assessments. scRNA-seq elucidated molecular mechanisms, validated by RT-qPCR, IHC, flow cytometry, and Western blot. Discussion: ResultsResults demonstrated that Plantaricin BM-1 significantly suppressed tumorigenesis, colon shortening, serum TNF-α levels, and pathological damage. scRNA-seq revealed a 17.38% increase in tumor-infiltrating T cells and a 9.29% expansion of cytotoxic CD8⁺ T cells. Key cytotoxic genes (Gzma, Gzmb, Fasl) were upregulated in CD8⁺ T cells, while the ERK/AP1 pathway was suppressed. Consistently, Plantaricin BM-1 downregulated ERK, AP1, and pro-apoptotic Bim Discussion: These findings provide mechanistic insights for developing Plantaricin BM-1 as an anti-CRC agent.

Indexed as

ApoptosisBacteriocinsCD8-Positive T-LymphocytesColorectal NeoplasmsT-Lymphocytes, CytotoxicAnimalsBcl-2-Like Protein 11Disease Models, AnimalHumansMaleMAP Kinase Signaling SystemMiceMice, Inbred C57BLSignal TransductionTranscription Factor AP-1BacteriocinsBcl-2-Like Protein 11Transcription Factor AP-1apoptosiscolorectal cancercytotoxic CD8+ T cellsplantaricin BM-1scRNA-seq

Identifiers

PMID41983138
PMCPMC13071030

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.