ArticleFrontiers in immunology2026
Endometrial immune dysregulation shapes CD8
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Background: The recurrent implantation failure (RIF) remains a major clinical challenge in assisted reproduction. While endometrial immune dysregulation is implicated, its specific role and interaction with clinical factors are poorly defined. The lack of integrated, multimodal predictive models that combine clinical history with immune profiling limits personalized management. Methods: This study conducted a retrospective cohort study of 110 RIF patients, collecting comprehensive clinical and immune parameters. Traditional statistics and machine learning were employed to identify key predictors and build predictive models. Model interpretability was assessed using SHAP analysis, and causal pathways were explored Results: Previous implantation failure number was the strongest negative predictor (aOR = 0.74, 95% CI 0.60-0.91, Conclusion: This integrated clinical-immune signature underscores the pivotal, threshold-dependent role of endometrial CD8
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