ArticleACS applied nano materials2026
Metal-Coordinated His-Tag Functionalization of Polymeric Nanogels for Therapeutic Applications.
Article in ACS applied nano materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Nanogels (NGs) are versatile polymeric nanocarriers with high drug loading capacity and colloidal stability, making them pivotal candidates for targeted biomedical applications. Surface functionalization with biomolecules is essential for selective targeting therapies; however, conventional covalent conjugation can compromise the activity of sensitive ligands (e.g., proteins and antibodies). The His-tag strategy offers a reversible, oriented binding through coordination with transition metal ions, widely used in protein purification, but scarcely explored for polymeric NG decoration. Here, we developed polyallylamine-based NGs via an emulsion-evaporation process. The NG outer layer was functionalized with lysine-conjugated nitrilotriacetic acid to chelate Ni
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