Evidence map›Paper›PMID 41983086›Full record

ArticleACS applied nano materials2025

Designing MOF-Thermogel Nanocomposites for Differential Multidrug Release in Combination Cancer Therapy.

Wenyi Zeng, Tristan T Y Tan, Qianyu Lin, Wei Wei Loh, Yan Hui Lee, Michael R Reithofer, Xian Jun Loh, Jia Min Chin, Jason Y C Lim

Abstract read
In one paragraph

Article in ACS applied nano materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wenyi ZengInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Tristan T Y TanInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.ORCID https://orcid.org/0000-0001-5391-7232
Qianyu LinInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Wei Wei LohInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Yan Hui LeeInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Michael R ReithoferInstitute of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria.ORCID https://orcid.org/0000-0002-6328-1896
Xian Jun LohInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.ORCID https://orcid.org/0000-0001-8118-6502
Jia Min ChinInstitute of Functional Materials and Catalysis, Faculty of Chemistry, University of Vienna, Währinger Str. 42, 1090 Vienna, Austria.ORCID https://orcid.org/0000-0002-0540-1597
Jason Y C LimInstitute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.ORCID https://orcid.org/0000-0002-8020-1720

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combination chemotherapy is a leading strategy for advanced cancer treatment, bringing about improved therapeutic responses compared with single-drug chemotherapy. However, achieving the required sequence of drug delivery needed for optimal therapeutic benefits via a single-drug delivery system remains highly challenging, often involving systems of considerable complexities. Herein, we report the design of composites comprising nanoscale metal-organic frameworks (MOFs) and temperature-responsive hydrogels (thermogels) as versatile, modular, yet simple-to-formulate platforms for controlled, localized release of combination chemotherapeutics, which can be used for solid tumor treatment. First, the encapsulation behavior, drug-host interactions, and

Indexed as

controlled drug releasehydrogel compositeslocalized tumor treatmentmetal−organic frameworksynergistic chemotherapy

Identifiers

PMID41983086
PMCPMC13073680

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.