ReviewFrontiers in sports and active living2026
The role of exercise-induced myokines in cancer-associated inflammation and immune regulation: mechanisms and prospects.
Review in Frontiers in sports and active living, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Exercise-induced myokines and the muscle-tumor axis in obesity-driven gynecological cancers: a narrative review.Frontiers in oncology · 2026Review
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Authors and funding
8 authors.
Funding
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Abstract
Skeletal muscle is increasingly recognized as an endocrine organ, and contraction-induced myokines are viewed as key mediators of the systemic benefits of exercise. This review synthesizes evidence on the roles and molecular mechanisms of major myokines-including IL-6, irisin, SPARC, oncostatin M (OSM), and decorin-in exercise-associated modulation of cancer-related inflammation and tumor progression. We propose two principal routes: direct effects on tumor cells (e.g., reduced proliferation and metastatic potential) and indirect effects mediated by remodeling of the tumor immune microenvironment. Nevertheless, the literature remains heterogeneous, and reported effects are strongly context dependent, contributing to ongoing debate. Personalized exercise prescriptions, together with deeper mechanistic studies, may accelerate the clinical translation of myokines as biomarkers and potential therapeutic targets.
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