ArticleFrontiers in nutrition2026
UHPLC-Q-TOF-MS/MS profiling of resin glycosides and their lipase inhibitory activity in leaves of selected sweet potato (
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Resin glycosides (RGs) found in the aerial parts of sweet potato are health promoting agents that can be reclaimed from the by-products of sweet potato plantation as agriceuticals for combating obesity. However, RGs have complex structural variations across various sweet potato cultivars, along with an unclear structure-activity relationship. To address this gap, nine types of sweet potato leaves were evaluated, including "Shangshu 19", "Xuzi 20-1", "Xushu 24", "Xushu 32", "Yanshu 25", "Blackheart", "Blackie", and two "Beniazuma" samples. Methods: RG-rich extracts were obtained from sweet potato leaves by using dichloromethane extraction. Pancreatic lipase (PL) inhibitory activity was then determined by a p-nitrophenyl palmitate (pNPP)-based assay. Individual RG profiles were characterized and semi-quantified by UHPLC-Q-TOF-MS/MS, followed by multivariate analysis to evaluate cultivar-dependent variations and identify spectral features associated with PL inhibition. Results: Xushu 32 and Blackheart cultivars exhibited the highest PL inhibitory activities with an Orlistat equivalent (OE) of 2.44 ± 0.30 and 2.02 ± 0.10 ng orlistat/μg extracts, respectively. In total, 128 RGs were tentatively identified based on UHPLC-Q-TOF-MS/MS analysis. Multivariate analysis revealed cultivar-dependent differences in RG profiles and identified four RGs as potential marker compounds associated with PL inhibition. All four RGs were pentasaccharides featuring 2-methylbutyric and dodecanoic acid as side chains. Further mechanistic study revealed that long-chain fatty acid esters or a macrocyclic lactone moiety on the RG backbone may play a key role in conferring inhibition. Discussion: Taken together, these findings may serve as valuable guidelines for foodomic analysis of RGs and cultivar selection in developing anti-obesity functional foods derived from agricultural by-products.In addition, we would like to double-check that the formatting of Table 1 is maintained as in the original manuscript we provided. The current proof version includes additional internal table lines that slightly alter the intended meaning of the table.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.