Evidence map›Paper›PMID 41983061›Full record

ReviewExtracellular vesicles and circulating nucleic acids2026

Circulating extracellular vesicle DNA (EV-DNA) and cell-free DNA in ovarian cancer: pathological relevance and diagnostic applications.

Dominic Guanzon, Rakesh Sankar, Pragati Lodha, Reshinthine Purushothaman, Shiyuan Huang, Nanthini Jayabalan, Madushani Dahanayake, Emtiaz Ahmed, Pingping Han, Mostafa Kamal Masud and 2 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Extracellular vesicles and circulating nucleic acids, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dominic GuanzonTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane QLD 4029, Australia.
Rakesh SankarTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane QLD 4029, Australia.
Pragati LodhaTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane QLD 4029, Australia.
Reshinthine PurushothamanTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane QLD 4029, Australia.
Shiyuan HuangTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane QLD 4029, Australia.
Nanthini JayabalanCentre for Biomedical Technologies, Queensland University of Technology (QUT), Brisbane QLD 4000, Australia.
Madushani DahanayakeAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane QLD 4076, Australia.
Emtiaz AhmedAustralian Institute of Bioengineering and Nanotechnology, The University of Queensland, Brisbane QLD 4076, Australia.
Pingping HanUQ Centre for Extracellular Vesicle nanomedicine, The University of Queensland, Brisbane QLD 4029, Australia.
Mostafa Kamal MasudUQ Centre for Extracellular Vesicle nanomedicine, The University of Queensland, Brisbane QLD 4029, Australia.
Yusuke YamauchiUQ Centre for Extracellular Vesicle nanomedicine, The University of Queensland, Brisbane QLD 4029, Australia.
Carlos SalomonTranslational Extracellular Vesicles in Obstetrics and Gynae-Oncology Group, University of Queensland Centre for Clinical Research, Faculty of Medicine, The University of Queensland, Brisbane QLD 4029, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ovarian cancer is one of the leading causes of gynecologic cancer-related mortality in women. However, a significant proportion of ovarian cancer cases are only detected at an advanced stage (III or IV) and are complicated to treat because of metastasis to the peritoneum. This challenge is compounded by vague symptoms and insufficient screening methods for early ovarian cancer detection. A promising solution is liquid biopsy, where the presence of biomarkers (proteins, lipids, and nucleic acids) associated with cancer is identified in the blood circulation. This approach facilitates the real-time monitoring of cancer progression and treatment effects in a non-invasive manner. This contrasts with traditional tumor biopsy, where only a small portion of the tumor is sampled, serial sampling of the tumor is impractical, or sometimes, tumor biopsy is not feasible. This review discusses the cell-free and extracellular vesicle components in blood, highlighting their DNA as a target in liquid biopsies for cancer diagnostics, with a specific emphasis on ovarian cancer. It also underscores the need for further research into the biological underpinnings and functional roles of these DNA fragments to integrate them into multi-omics approaches for detailed insights into tumor biology and treatment resistance in ovarian cancer.

Indexed as

cancer diagnosticscell-free DNAextracellular vesicle-DNAliquid biopsymulti-omicsnanotechnologiesOvarian cancertreatment resistance

Identifiers

PMID41983061
PMCPMC13074317

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.