Evidence map›Paper›PMID 41983010›Full record

ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2026

Elevated Serum Concentrations of Lacosamide and Perampanel in a Pediatric Patient Following Coadministration of Clarithromycin for

Shotaro Meguro, Toru Imai, Wakako Ishii, Emiko Momoki, Tadayasu Kawaguchi, Kengo Matsuda, Shintaro Watanabe, Susumu Ootsuka

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Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shotaro MeguroDepartment of Pharmacy (SM, TI, SO), Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, Japan.
Toru ImaiDepartment of Pharmacy (SM, TI, SO), Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, Japan.
Wakako IshiiDepartment of Pediatrics (WI, EM, TK, KM, SW), Division of Pediatrics, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Emiko MomokiDepartment of Pediatrics (WI, EM, TK, KM, SW), Division of Pediatrics, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Tadayasu KawaguchiDepartment of Pediatrics (WI, EM, TK, KM, SW), Division of Pediatrics, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Kengo MatsudaDepartment of Pediatrics (WI, EM, TK, KM, SW), Division of Pediatrics, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Shintaro WatanabeDepartment of Pediatrics (WI, EM, TK, KM, SW), Division of Pediatrics, Nihon University School of Medicine, Itabashi-ku, Tokyo, Japan.
Susumu OotsukaDepartment of Pharmacy (SM, TI, SO), Nihon University Itabashi Hospital, Itabashi-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lacosamide (LCM) and perampanel (PER) are antiepileptic drugs eliminated, in part, by cytochrome P450 (CYP) 3A4. However, clinical reports of their interactions are limited. Here, we report the case of a 12-year-old girl with a history of infantile epileptic spasms syndrome, treated with LCM, PER, valproic acid (VPA), and levetiracetam (LEV), who was diagnosed with

Indexed as

case reportclarithromycinCYP3A4drug interactionslacosamideperampanel

Identifiers

PMID41983010
PMCPMC13075393

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.