Evidence map›Paper›PMID 41983009›Full record

ArticleThe journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG2026

Low-Dose Versus High-Dose Methylprednisolone and Impact on Duration of Noninvasive Bilevel Positive Airway Pressure in Pediatric Severe Asthma Exacerbations.

Alyssa Wallace, Sarah Belz, Jessica Lundeen, Elizabeth Elliott, Parisa Kaviany, Matthew Sharron, Boh Song

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Article in The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Alyssa WallaceDivision of Pharmacy (AW, SB, JL, BS), Department of Critical Care (EE, MS), Department of Pulmonary and Sleep Medicine (PK), Children's National Hospital, Washington, DC.
Sarah BelzDivision of Pharmacy (AW, SB, JL, BS), Department of Critical Care (EE, MS), Department of Pulmonary and Sleep Medicine (PK), Children's National Hospital, Washington, DC.
Jessica LundeenDivision of Pharmacy (AW, SB, JL, BS), Department of Critical Care (EE, MS), Department of Pulmonary and Sleep Medicine (PK), Children's National Hospital, Washington, DC.
Elizabeth ElliottDivision of Pharmacy (AW, SB, JL, BS), Department of Critical Care (EE, MS), Department of Pulmonary and Sleep Medicine (PK), Children's National Hospital, Washington, DC.
Parisa KavianyDivision of Pharmacy (AW, SB, JL, BS), Department of Critical Care (EE, MS), Department of Pulmonary and Sleep Medicine (PK), Children's National Hospital, Washington, DC.
Matthew SharronDivision of Pharmacy (AW, SB, JL, BS), Department of Critical Care (EE, MS), Department of Pulmonary and Sleep Medicine (PK), Children's National Hospital, Washington, DC.
Boh SongDivision of Pharmacy (AW, SB, JL, BS), Department of Critical Care (EE, MS), Department of Pulmonary and Sleep Medicine (PK), Children's National Hospital, Washington, DC.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveCorticosteroids are frequently used in asthma exacerbation management; however, there are few data on optimal dosing for patients needing positive pressure ventilation. The purpose of this study is to investigate the relationship between steroid dosing and asthma outcomes, specifically as it relates to patients admitted to the pediatric intensive care unit (PICU) who require noninvasive bilevel positive airway pressure (NBPAP) ventilation.

methodsThis retrospective study evaluated patients older than 2 years, admitted to the PICU and initiated on NBPAP for an asthma exacerbation during the study period. The methylprednisolone low-dose (0.5 mg/kg/dose with a maximum of 15 mg every 6 hours) and high-dose (1 mg/kg/dose with a maximum of 60 mg every 6 hours) strategies were used to determine the cohorts. The NBPAP duration and PICU and hospital length of stay were recorded.

resultsA total of 197 patients were included in the study: 95 patients made up the low-dose cohort and 102 patients were in the high-dose cohort. The patients in the low-dose cohort had a median time on NBPAP of 25.2 hours compared with 25.5 hours in the high-dose cohort (p = 0.949). There was also no -difference in PICU and hospital length of stay as well as inpatient steroid duration.

conclusionsNo difference was observed between low-dose and high-dose methylprednisolone on -duration of NBPAP in pediatric severe asthma exacerbations.

Indexed as

asthmabiphasic continuous positive airway pressurecorticosteroidsdisease exacerbationlength of staypediatric intensive care units

Identifiers

PMID41983009
PMCPMC13075370

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.