ArticleTranslational pediatrics2026
Baseline bicarbonate level is associated with apnea of prematurity in preterm neonates with neonatal jaundice: insights from the Medical Information Mart for Intensive Care III (MIMIC-III) database.
Article in Translational pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Apnea of prematurity (AOP) and neonatal jaundice are among the most common diagnoses in the neonatal intensive care unit (NICU). This study aims to evaluate the association between baseline serum bicarbonate levels and the risk of AOP in preterm neonates with neonatal jaundice. Methods: Using data from the MIMIC-III database (2001-2012), we identified 2,170 preterm neonates diagnosed with neonatal jaundice. Baseline bicarbonate was defined as the initial serum level measured within 24 hours of admission and categorized into quartiles (Q1-Q4). Multivariate logistic regression, mediation analysis, propensity score matching (PSM), subgroup analyses, and restricted cubic spline (RCS) analysis were performed. Results: Baseline bicarbonate levels showed a significant inverse association with AOP risk when analyzed as a continuous variable {Model 1: odds ratio (OR) =0.964 [95% confidence interval (CI): 0.937-0.992], P=0.01; Model 2: OR =0.919 (95% CI: 0.895-0.944), P<0.001; Model 3: OR =0.912 (95% CI: 0.888-0.936), P<0.001}. When bicarbonate levels were divided into quartiles, individuals with baseline levels in the Q2 range exhibited the lowest risk of AOP [Model 1: OR =0.545 (95% CI: 0.423-0.702), P<0.001; Model 2: OR =0.383 (95% CI: 0.300-0.488), P<0.001; Model 3: OR =0.363 (95% CI: 0.285-0.461), P<0.001; Model 4: OR =0.758 (95% CI: 0.579-0.992), P=0.044]. Further evidence from mediation analysis and subgroup analysis following PSM consistently supported the mediating role of caffeine treatment (indirect effect: β=-0.059, P<0.001; direct effect: β=0.048, P=0.97). RCS analysis revealed a non-linear relationship between bicarbonate levels and AOP risk (P for nonlinear <0.05). Conclusions: This study found that lower baseline bicarbonate levels were linked to higher AOP risk in preterm neonates with jaundice. Caffeine treatment fully mediated this nonlinear association, and those with bicarbonate levels in Q2 (16-19 mEq/L) had the lowest AOP risk.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.