ArticleChemical science2026
Molecular jackhammers induce intracellular calcium release and skeletal muscle contraction by vibronic-driven action.
Article in Chemical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intracellular calcium release (ICR) is of fundamental importance for numerous physiological and pathological processes, from cell differentiation to neurotransmitter release and muscle contraction. The ability to precisely control ICR is crucial for understanding cellular signaling mechanisms and developing therapeutic interventions for calcium-related disorders. Light-induced ICR offers numerous advantages over conventional approaches, including superior specificity, precise spatiotemporal control, excellent reproducibility, and minimal invasiveness. Here, we demonstrate that cyanine dyes function as molecular jackhammers (MJHs) to induce ICR in human embryonic kidney (HEK) 293 and immortalized mouse myoblast C2C12 cells through vibronic-driven action (VDA) following red light (640 nm) activation. VDA generates longitudinally and axially coordinated whole-molecule vibrations, enabling mechanical interactions with cells. Structure-activity relationship studies of twenty synthesized MJHs demonstrated that sulfonate-containing derivatives most effectively triggered intracellular calcium release while exhibiting minimal cytotoxicity. Mechanistic studies showed that MJH-induced calcium release operates through the inositol-triphosphate (IP
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.