ArticleNature and science of sleep2026
Association of Complete Blood Count-Derived Inflammatory Markers with Trouble Sleeping: Evidence from Population Data and Experimental Sleep Deprivation.
Article in Nature and science of sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Deciphering the Biological Basis of Inflammatory Markers Associated with Trouble Sleeping [Letter].Nature and science of sleep · 2026Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Trouble sleeping is a common pathophysiological feature underlying sleep disorders and affects both the number and function of immune cells. This study investigated the associations between complete blood count (CBC)-derived inflammatory markers and trouble sleeping, aiming to provide a simple and rapid reference for evaluating sleep-related conditions. Patients and methods: A total of 39,156 participants from the 2011-2018 NHANES cycles were included. Survey-weighted multivariable logistic regression was performed to examine the associations between CBC-derived inflammatory markers and trouble sleeping. Restricted cubic spline models were applied to assess potential nonlinear relationships, and stratified analyses were conducted for robustness. Additionally, a human study in healthy volunteers evaluated the effects of short-term sleep deprivation (36 h) and subsequent recovery on CBC-derived inflammatory markers and circulating pro-inflammatory cytokines. Results: Participants with trouble sleeping had shorter sleep duration and elevated levels of several CBC-derived inflammatory markers compared with those without trouble sleeping. Sleep insufficiency was particularly associated with increased monocyte-to-lymphocyte ratio (MLR, Conclusion: The findings highlight the link between trouble sleeping and CBC-derived inflammatory markers, with SIRI emerging as a potential predictor of trouble sleeping and IL-6 as a key cytokine involved in the inflammatory response to sleep deprivation.
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