ArticleJournal of hepatocellular carcinoma2026
The Impact of Spatiotemporal Patterns of Tumor Recurrence on Prognosis in Hepatocellular Carcinoma Patients Undergoing Surgery After Conversion Therapy.
Article in Journal of hepatocellular carcinoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Purpose: To characterize the spatiotemporal patterns of recurrence and assess their impact on survival in hepatocellular carcinoma (HCC) patients undergoing curative resection after conversion therapy. Methods: We retrospectively analyzed 80 HCC patients who achieved successful conversion and underwent resection between January 2019 and February 2025. Recurrence was classified by timing (early ≤10.5 months vs. late >10.5 months, determined by maximally selected log-rank statistics) and location (intrahepatic vs. extrahepatic) of the first recurrence. Exploratory analyses were also conducted using a 12-month cutoff to align with clinical practice. Post-recurrence survival (PRS), overall survival, and recurrence-free survival were evaluated using Kaplan-Meier analysis. The multivariable Cox models were used to calculate the adjusted hazard ratio and 95% confidence interval for PRS. Results: Recurrence occurred in 52.5% of patients. Early recurrence was associated with significantly worse PRS than late recurrence ( Conclusion: In this cohort, time to recurrence is the dominant prognostic factor, with recurrence site providing additional stratification. These findings support the use of spatiotemporal recurrence patterns for risk-adapted surveillance and adjuvant strategies.
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