Endocyclic Trisubstituted Hydroxylamine Isosteres of Basic Amines for ADME Modulation and Reduction of hERG Activity.

Iftikhar Khan, Asiri A Hettikankanamalage, Yizhi Cui, David Crich

Abstract read

In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Energetics of Formation and Fragmentation of Carbon-Centered Radicals α- to Nitrogen and Oxygen inACS physical chemistry Au · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Iftikhar KhanInnovations in Drug Discovery Program, Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.ORCID https://orcid.org/0009-0002-7734-2888

Asiri A HettikankanamalageInnovations in Drug Discovery Program, Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.ORCID https://orcid.org/0000-0003-3310-1038

Yizhi CuiInnovations in Drug Discovery Program, Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.ORCID https://orcid.org/0009-0005-1369-9396

David CrichInnovations in Drug Discovery Program, Department of Pharmaceutical and Biomedical Sciences, University of Georgia, 250 West Green Street, Athens, Georgia 30602, United States.ORCID https://orcid.org/0000-0003-2400-0083

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The attachment of solvent-exposed basic amines to kinase inhibitors via an aliphatic chain is a strategy commonly employed to increase aqueous solubility but one that is often complicated by increased human ether-a-go-go (hERG) activity and reduced metabolic stability. Extrapolating from previous work on the replacement of the solubilizing morphilinoalkyl and

Indexed as

1,2,5-oxadiazepaneBioisosterehERGhydroxylaminePAK1

Identifiers

PMID41982738

DOI10.1021/acsmedchemlett.6c00062

PMCPMC13071656

What OpenQuestion holds

Textmetadata

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.