Evidence map›Paper›PMID 41982724›Full record

ArticleACS medicinal chemistry letters2026

Discovery and Optimization of a Trichloroacetamidine Scaffold as a Novel Antibacterial against Multidrug-Resistant

Leticia Christina Pires Gonçalves, Zakaria Moutaoukil, Juan A Garcia-Sanchez, Safeh Khemiri, Rachid Benhida, Pauline Meola, Patrick Munro, Raymond Ruimy, Laurent Boyer, Cyril Ronco

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Leticia Christina Pires GonçalvesInstitut de Chimie de Nice, CNRS UMR7272, Université Côte d'Azur, Nice 06108, France.
Zakaria MoutaoukilInstitut de Chimie de Nice, CNRS UMR7272, Université Côte d'Azur, Nice 06108, France.
Juan A Garcia-SanchezUniversité Côte d'Azur, INSERM, C3M, Nice 06108, France.
Safeh KhemiriInstitut de Chimie de Nice, CNRS UMR7272, Université Côte d'Azur, Nice 06108, France.
Rachid BenhidaInstitut de Chimie de Nice, CNRS UMR7272, Université Côte d'Azur, Nice 06108, France.
Pauline MeolaUniversité Côte d'Azur, INSERM, C3M, Nice 06108, France.
Patrick MunroUniversité Côte d'Azur, INSERM, C3M, Nice 06108, France.
Raymond RuimyUniversité Côte d'Azur, INSERM, C3M, Nice 06108, France.
Laurent BoyerUniversité Côte d'Azur, INSERM, C3M, Nice 06108, France.
Cyril RoncoInstitut de Chimie de Nice, CNRS UMR7272, Université Côte d'Azur, Nice 06108, France.ORCID https://orcid.org/0000-0002-9023-5940

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The global spread of multidrug-resistant bacterial strains poses a major threat to public health and underscores the urgent need for new antibacterial chemotypes. We report here the discovery and optimization of a novel scaffold,

Indexed as

Antibacterial agentsFocused screening hit discoveryGram-positive selective compoundsMultidrug-resistant Staphylococcus aureus (MRSA)N-(benzothiazol-2-yl)imidamide derivativesStructure−activity relationship (SAR) optimizationTrichloroacetamidine scaffold

Identifiers

PMID41982724
PMCPMC13071640

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.