Evidence map›Paper›PMID 41982721›Full record

ArticleACS medicinal chemistry letters2026

Design, Synthesis, and Biological Evaluation of Selective CDK4/9 Inhibitors.

Siqi Li, Xiaotang Yang, Weiyi Yin, Wencui Zhang, Zhuorong Li, Jinping Hu, Yanping Li

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Siqi LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Xiaotang YangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Weiyi YinInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Wencui ZhangInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zhuorong LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.ORCID https://orcid.org/0000-0001-5748-7444
Jinping HuInstitute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.ORCID https://orcid.org/0000-0003-2382-2034
Yanping LiInstitute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.ORCID https://orcid.org/0000-0002-5771-0252

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Simultaneous inhibition of cell cycle CDKs and transcriptional CDKs may provide a novel strategy for cancer therapy. Starting from a pan-CDK inhibitor, a series of novel 2-((4-substitutedphenyl)-amino)-pyrrolo-[2,3-

Indexed as

antiproliferationCDK4/9 inhibitorspyrrolo[2,3-d]pyrimidine derivativesstructure−activity relationshipsynthesis

Identifiers

PMID41982721
PMCPMC13071620

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.