Evidence map›Paper›PMID 41982714›Full record

ArticleACS medicinal chemistry letters2026

Functional Evaluation of Tetrahydroisoquinoline-Derived Ligands Reveals Distinct Modulatory Profiles at the Muscarinic M1 Receptor.

Juan P González-Gutiérrez, Damián A Castillo-Ríos, Ignacio A González-Gutiérrez, Dante R Palma-Ruíz, Isabel A Vidal-Beltrán, Ingrid V Carvacho, Fernando A Hinostroza

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Juan P González-GutiérrezDepartamento de Física y Química, Facultad de Ingeniería, Universidad Autónoma de Chile, Talca 3467987, Chile.
Damián A Castillo-RíosDepartamento de Física y Química, Facultad de Ingeniería, Universidad Autónoma de Chile, Talca 3467987, Chile.
Ignacio A González-GutiérrezInterno de Medicina, Facultad de Medicina y Ciencias de la salud, Universidad Mayor, Huechuraba 8580000, Chile.
Dante R Palma-RuízFacultad de Ciencias Agrarias y Forestales, Universidad Católica del Maule, Talca 3460000, Chile.
Isabel A Vidal-BeltránCentrode de Investigación de Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca 3460000, Chile.
Ingrid V CarvachoDepartamento de Medicina Traslacional, Facultad de Medicina, Universidad Católica del Maule, Talca 3460000, Chile.
Fernando A HinostrozaCentrode de Investigación de Estudios Avanzados del Maule (CIEAM), Vicerrectoría de Investigación y Postgrado, Universidad Católica del Maule, Talca 3460000, Chile.ORCID https://orcid.org/0000-0001-8001-5808

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The muscarinic acetylcholine M1 receptor (M1-mAChR) is a key regulator of cognitive processes and remains an attractive target for the modulation of central cholinergic signaling. In this study, tetrahydroisoquinoline-derived ligands (THQ140, THQ790) and a structurally related compound (QPB) were evaluated for their ability to modulate M1-mAChR activity. Intracellular Ca

Indexed as

calcium imagingM1 receptormolecular dynamics simulations

Identifiers

PMID41982714
PMCPMC13071651

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.