ArticleBrain communications2026
Multi-level language deficits in behavioural frontotemporal degeneration and related disorders.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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11 authors.
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Abstract
Language is essential to social communication. Its complexity and hierarchical organization, from low-level operations to high-order integrative processes, may provide valuable diagnostic insights in neurodegeneration beyond classical aphasia syndromes. However, systematic investigations in these conditions, particularly in behavioural variant frontotemporal degeneration (bvFTD), remain scarce. To refine differential diagnosis, an exhaustive characterization of language functions is required. We systematically compared multi-level language functioning across bvFTD, Alzheimer's disease (AD) and primary psychiatric disorders (PPD), within an integrative neurolinguistic framework distinguishing lexical, syntactic and discursive levels, together with a cross-modal transposition/transcoding dimension. A total of 85 patients (including 34 with bvFTD, 30 with AD, 21 with PPD) and 40 matched healthy controls underwent an extensive language assessment using the GREMOTs battery. Composite, quantitative as well as qualitative indices were computed for each linguistic level. Structural MRI data were analysed using voxel-based morphometry (
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