ReviewMediastinum (Hong Kong, China)2026
The evolving role of interventional pulmonology with endobronchial ultrasonography in the diagnosis of lymphoma: a narrative review.
Review in Mediastinum (Hong Kong, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Transbronchial Mediastinal Cryobiopsy-Rising to the Challenge.Respirology (Carlton, Vic.) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: For patients undergoing evaluation for mediastinal/hilar adenopathy or masses suspicious for lymphoma, endobronchial ultrasonography (EBUS)-transbronchial needle aspiration (TBNA) offers a lower-risk alternative to surgical or percutaneous biopsy. While the utility of EBUS-TBNA is well established in lung cancer diagnosis, including biomarker analysis, its role in lymphoma is more limited. This is because for accurate subtyping of lymphoma, larger intact tissue specimens are needed and EBUS-TBNA can only provide cytology specimens. To address this limit, various needle sizes and/or sampling techniques such as cryobiopsy have been investigated to improve diagnostic sensitivity for lymphoma. In this review, we discuss the current evidence for these various techniques in the diagnosis of lymphoma. Methods: We conducted a narrative review by searching PubMed/MEDLINE, Embase and Google Scholar for articles published during 1980-2025 using search terms including "EBUS", "EBUS-TBNA", "endobronchial ultrasound", "bronchoscopy", "lymphoma diagnosis", "mediastinal lymphadenopathy" and "interventional pulmonology". Only articles written in English that focused on evaluation of diagnostic sensitivity, specimen adequacy, and interventional techniques for suspected lymphoma were included in our review. Key Content and Findings: Several studies suggested that EBUS-TBNA combined with appropriate immunohistochemical, flow cytometry, cytogenetic, and molecular studies can achieve an accurate lymphoma diagnosis. However, its sensitivity for Conclusions: For patients undergoing evaluation for mediastinal/hilar adenopathy or masses suspicious for lymphoma, EBUS with TBNA, or with other techniques such as cryobiopsy, may be a reasonable first diagnostic step, as it is less invasive with a better safety profile than surgical excision of these lymph nodes. Prospective studies are needed to establish best practices for the use of EBUS to diagnose lymphoma.
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Registered trials
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