ReviewMediastinum (Hong Kong, China)2026
Does needle size affect the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration for malignant lymphoma?-a narrative review.
Review in Mediastinum (Hong Kong, China), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Transbronchial Mediastinal Cryobiopsy-Rising to the Challenge.Respirology (Carlton, Vic.) · 2026Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Objective: Bronchoscopic diagnosis of malignant lymphoma is challenging, because bronchoscopic tissues are often relatively small. Recently, a 19-gauge needle (19G) was developed to obtain larger tissue cores; however, its effectiveness in improving the diagnostic yields remains controversial. Therefore, in this narrative review, we aimed to summarize recent findings and evaluate the usefulness of different needle sizes for diagnosing malignant lymphoma. Methods: A comprehensive and systematic online literature search of PubMed was conducted using the keywords ("malignant lymphoma" OR "lymphoma") and ("endobronchial ultrasound" OR "endobronchial ultrasound guided" OR "endobronchial ultrasound guided transbronchial needle aspiration" OR "EBUS" OR "EBUS-TBNA" OR "needle size"). Key Content and Findings: Three prospective and 13 retrospective studies were included. Approximately 50% of the procedures were performed under moderate sedation, and the remainder under general anesthesia. Regarding subtype determination, the diagnostic yield of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) ranged from 50% to 65% with a 19G, and from 19% to 88% with a 21G and 22G. Supportive methods such as rapid on-site cytological evaluation (ROSE) and flow cytometry were performed variably, depending on the bronchoscopist's preference or institutional resources. Conclusions: When ROSE and flow cytometry are available, there seems to be no significant difference in diagnostic yield for lymphoma subtype determination between 19G and 21/22G during EBUS-TBNA.
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