ReviewFrontiers in neuroscience2026
Targeting glial scar formation for spinal cord injury: mechanisms, strategies, and research progress review.
Review in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spinal cord injury is often followed by the formation of a glial scar which acts as a major barrier for axonal regrowth and recovery after spinal injuries. The glial scar consists of a complex mixture of cells and extracellular molecules that have different effects; they protect injured areas from further damage but at the same time inhibit axonal sprouting. We have performed a thorough and detailed study of the underlying biological mechanisms in scarring by focusing on the interactions among the astrocytes, microglial, fibroblastic, or immune-related components. With recent advances in experimental model systems and translational studies, here we review therapeutic interventions aimed to modulate scarring, including gene transfer, cell delivery, immunomodulation, and biomaterial scaffolds. Integrating recent advances, the present review aims at providing an effective theoretical basis as well as new treatment approaches for the treatment of SCI patients.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.