ArticleJournal of inflammation research2026
Identification of a Diagnostic Gene Signature Associated with Centrosome Amplification in Pressure Injuries: A Cross-Sectional Transcriptome and Machine Learning Study.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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7 authors.
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Abstract
Purpose: Centrosome amplification (CA) contributes to cancer but remains poorly characterized in non-neoplastic conditions such as pressure injuries (PI). This study investigated CA-related genes (CARGs) in PI to identify potential therapeutic targets. Patients and Methods: Transcriptomic data from 15 patients with PI and 15 healthy control blood samples were analyzed. Differentially expressed genes were intersected with CARGs, and key genes were identified using machine learning algorithms and receiver operating characteristic curve analysis. A nomogram was constructed, and underlying mechanisms were investigated using functional enrichment, immune infiltration, drug prediction, and quantitative reverse transcription polymerase chain reaction (RT-qPCR) analyses. Results: Conclusion: This study preliminarily identifies
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