ArticleFrontiers in cellular and infection microbiology2026
Bioinformatics based design of thermostable virus-like particles-based vaccine for foot-and-mouth disease serotype A and
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Foot-and-mouth disease (FMD) is a contagious disease affecting cloven footed animals. Existing vaccines although effective, has limitations of short immunity, needs cold chain maintenance, high biosafety levels facilities for production and inability to differentiate infected from vaccinated animals. Virus-like particles (VLPs) provide an alternative strategy and the structural integrity of VLPs at moderate temperatures or acidic pH plays major role as they destabilize the capsid and exhibits poor immunogenicity when used as vaccine. Stabilized capsids are developed using bioinformatics approach to predict amino acids in the structural proteins of the FMD virus, which may provide thermostability and can withstand live virus challenge. Methods: Baculovirus expression system offer an attractive method for producing VLPs of foot-and-mouth disease virus, which mimics the native virus and elicits protective immune response. Results: The demonstration of capsids of FMDV in the transmission electron micrograph confirmed the expression of AM-3 VLPs. Thermostability studies revealed AM-3 had significantly low degradation (62.5%) on 15 days post storage at 37°C amongst all VLPs and validated by Conclusion: The thermostable AM-3 VLPs produced based on bioinformatics without compromising the structural integrity, could confer protective immunity in preclinical studies and which can serve as a potential thermostable candidate vaccine for FMDV serotype A/IND/40/2000 for controlling FMD in ruminants.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.