Evidence map›Paper›PMID 41982456›Full record

ArticleFrontiers in cellular and infection microbiology2026

New insights for an old drug: difluoromethylornithine boosts the trypanocidal action of benznidazole on

Santiago José Martínez, María Cristina Vanrell, Xiaomo Li, Carolina Carrillo, David M Engman, Patricia Silvia Romano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. In Silico Screening ofBiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Santiago José MartínezLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
María Cristina VanrellLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.
Xiaomo LiCedars-Sinai Medical Center, Los Angeles, CA, United States.
Carolina CarrilloInstituto de Ciencia y Tecnología Dr. César Milstein, ICT Milstein-CONICET, Buenos Aires, Argentina.
David M EngmanCedars-Sinai Medical Center, Los Angeles, CA, United States.
Patricia Silvia RomanoLaboratorio de Biología de Trypanosoma cruzi y la célula hospedadora - Instituto de Histología y Embriología "Dr. Mario H. Burgos", IHEM-CONICET- Universidad Nacional de Cuyo, Mendoza, Argentina.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chagas disease, caused by the protozoan parasite

Indexed as

Chagas DiseaseEflornithineNitroimidazolesTrypanocidal AgentsTrypanosoma cruziAnimalsDisease Models, AnimalDrug SynergismDrug Therapy, CombinationFemaleInhibitory Concentration 50MiceParasitemiabenzonidazoleEflornithineNitroimidazolesTrypanocidal AgentsbenznidazoleChagas diseasecombined therapiesdifluoromethylornithineTrypanosoma cruzi

Identifiers

PMID41982456
PMCPMC13071062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.