Evidence map›Paper›PMID 41982427›Full record

ArticlePulmonary circulation2026

Chronic Thromboembolic Pulmonary Disease Phenotypes Using Upright Invasive Cardiopulmonary Exercise Testing.

Pradhab Kirupaharan, Jehad Azar, Xiaofeng Wang, Yifan Wang, Alice Goyanes, Tereza Izakovich, Michael Z Tong, Haytham Elgharably, Ihab Haddadin, Adriano R Tonelli and 1 more

Abstract read
In one paragraph

Article in Pulmonary circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Pradhab KirupaharanDepartment of Pulmonary Allergy and Critical Care Medicine. Integrated Hospital Care Institute. Cleveland Clinic Cleveland Ohio USA.ORCID https://orcid.org/0000-0002-0913-7092
Jehad AzarDepartment of Pulmonary and Critical Care Medicine Mayo Clinic Phoenix Arizona USA.
Xiaofeng WangDepartment of Quantitative Health Sciences Cleveland Clinic Cleveland Ohio USA.
Yifan WangDepartment of Quantitative Health Sciences Cleveland Clinic Cleveland Ohio USA.
Alice GoyanesDepartment of Pulmonary Allergy and Critical Care Medicine. Integrated Hospital Care Institute. Cleveland Clinic Cleveland Ohio USA.
Tereza IzakovichDepartment of Pulmonary Allergy and Critical Care Medicine. Integrated Hospital Care Institute. Cleveland Clinic Cleveland Ohio USA.
Michael Z TongHeart Vascular and Thoracic Institute Cleveland Clinic Cleveland Ohio USA.
Haytham ElgharablyHeart Vascular and Thoracic Institute Cleveland Clinic Cleveland Ohio USA.
Ihab HaddadinDepartment of Diagnostic Radiology Imaging Institute, Cleveland Clinic Cleveland Ohio USA.
Adriano R TonelliDepartment of Pulmonary Allergy and Critical Care Medicine. Integrated Hospital Care Institute. Cleveland Clinic Cleveland Ohio USA.
Gustavo A HeresiDepartment of Pulmonary Allergy and Critical Care Medicine. Integrated Hospital Care Institute. Cleveland Clinic Cleveland Ohio USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with chronic thromboembolic pulmonary disease (CTEPD) without resting pulmonary hypertension (PH) frequently experience dyspnea which is not explained by stationary assessment and therefore requires cardiopulmonary exercise testing for further diagnostic insight. Ventilatory inefficiency in CTEPD is commonly identified; however, consensus definitions are lacking. Upright iCPET and careful definition of ventilatory inefficiency (i.e., lack of reduction in VD/VT with exercise) may allow optimal characterization of patients with chronic thromboembolic disease and specifically helps correctly identify patients with preload insufficiency who may otherwise be misclassified or undiagnosed.

Indexed as

preload insufficiencypulmonary embolismpulmonary hypertensionventilatory inefficiency

Identifiers

PMID41982427
PMCPMC13071327

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.