Evidence map›Paper›PMID 41982390›Full record

ReviewEngineering microbiology2026

Effect of resistant starch type 5 on gut health through modulating gut microbiota.

Raju Ahmmed, Andrew Paff, Lingyan Kong, Songnan Li, Darrell W Cockburn, Libo Tan

Abstract readReview
In one paragraph

Review in Engineering microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Raju AhmmedDepartment of Human Nutrition, Hospitality and Sport Management, The University of Alabama, Tuscaloosa, AL 35487, USA.
Andrew PaffDepartment of Food Science, The Pennsylvania State University, State College, PA 16803, USA.
Lingyan KongDepartment of Human Nutrition, Hospitality and Sport Management, The University of Alabama, Tuscaloosa, AL 35487, USA.
Songnan LiDepartment of Human Nutrition, Hospitality and Sport Management, The University of Alabama, Tuscaloosa, AL 35487, USA.
Darrell W CockburnDepartment of Food Science, The Pennsylvania State University, State College, PA 16803, USA.
Libo TanDepartment of Human Nutrition, Hospitality and Sport Management, The University of Alabama, Tuscaloosa, AL 35487, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resistant starch is a dietary fiber that escapes digestion in the small intestine and undergoes fermentation by gut microbiota in the colon, producing beneficial short-chain fatty acids (SCFAs). Among the various types of resistant starch, resistant starch type 5 (RS5) has gained significant attention due to its unique and stable structural and functional properties. RS5 is a self-assembled V-type inclusion complex formed when amylose helices encapsulate guest molecules. This formation occurs through non-covalent interactions after the native starch structure is disrupted, and a guest compound is introduced. This structure provides enhanced resistance to enzymatic digestion, slows fermentation, and facilitates targeted release of bioactive molecules, making it effective in modulating gut health. RS5 promotes the proliferation of beneficial gut microbiota while suppressing pathogenic species, leading to increased SCFAs production, mostly butyrate, acetate, and propionate, which maintain intestinal integrity, reduces inflammation, and supports metabolic regulation. RS5 also contributes to preventing and managing chronic diseases such as obesity, type 2 diabetes, and colorectal cancer. While prior research has focused on its preparation methods and physicochemical characteristics, the influence of RS5 on gut microbiota and host health remains inadequately explored. This review summarizes the formation, classification, and structural diversity of RS5 complexes and how these factors influence digestibility and fermentation kinetics. Furthermore, it explores how RS5 modulates the composition and metabolic activity of the gut microbiota, enhancing SCFAs production. By comparing RS5 with other RS types, this review highlights its superior prebiotic potential and supports RS5-based functional food development for improving gut and metabolic health, targeting gut microecology.

Indexed as

Gut healthGut microbiotaPrebioticsResistant starchShort-chain fatty acidsStarch-guest complexes

Identifiers

PMID41982390
PMCPMC13064624

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.