Evidence map›Paper›PMID 41982319›Full record

ArticleNeurosurgery practice2026

Causes of Unfavorable Outcome in Patients With Aneurysmal Subarachnoid Hemorrhage in Clinical Grade World Federation of Neurosurgical Societies I-III Before Aneurysm Treatment: Impact of Adverse Events.

Bryndís Baldvinsdóttir, Erik Kronvall, Helena Aineskog, Paula Klurfan, Peter Alpkvist, Johanna Eneling, Per Enblad, Asgeir S Jakola, Mikael Svensson, Peter Lindvall and 3 more

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Article in Neurosurgery practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Bryndís BaldvinsdóttirDepartment of Clinical Sciences, Neurosurgery, Lund University, Lund, Sweden.
Erik KronvallDepartment of Clinical Sciences, Neurosurgery, Lund University, Lund, Sweden.
Helena AineskogDepartment of Clinical Sciences, Umeå University, Umeå, Sweden.
Paula KlurfanDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Peter AlpkvistDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Johanna EnelingDepartment of Clinical Sciences, Linköping University, Linköping, Sweden.
Per EnbladDepartment of Medical Sciences, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.
Asgeir S JakolaDepartment of Clinical Neuroscience, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Mikael SvenssonDepartment of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Peter LindvallDepartment of Clinical Sciences, Umeå University, Umeå, Sweden.
Elisabeth Ronne-EngströmDepartment of Medical Sciences, Section of Neurosurgery, Uppsala University, Uppsala, Sweden.
Jan HillmanDepartment of Clinical Sciences, Linköping University, Linköping, Sweden.
Ola G NilssonDepartment of Clinical Sciences, Neurosurgery, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe prognosis for functional independence after aneurysmal subarachnoid hemorrhage (aSAH) relies largely on patients' initial clinical status, age, and extent of the bleeding. However, some patients have poor outcome despite initially being in good clinical condition. The aim of this study was to analyze factors related to unfavorable outcome in patients with good clinical grade (World Federation of Neurosurgical Societies I-III) immediately before aneurysm treatment.

methodsProspectively gathered data of patients treated for aSAH in Sweden during the years 2014 to 2018 was analyzed. Preictal comorbidities, radiological findings, and aSAH-related and treatment-related adverse events (AEs) were analyzed using univariable and multivariable logistic regression. Outcome was assessed with Glasgow Outcome Scale Extended 1 year after the hemorrhage.

resultsOne thousand thirty-seven patients were treated for aSAH, of whom 607 patients were in good clinical grade before aneurysm treatment. Clinical follow-up was obtained for 520 of these patients. At follow-up, 102 (20%) had an unfavorable outcome. Factors increasing the risk of unfavorable outcome in this subgroup were advanced age (odds ratio [OR] 1.05, 95% CI 1.03-1.07), hydrocephalus (OR 1.80, 95% CI 1.04-3.14), delayed ischemic neurological deficit (OR 3.43, 95% CI 1.96-6.00), and AEs during aneurysm occlusion (OR 2.38, 95% CI 1.30-4.38).

conclusionAmong patients with good clinical status (World Federation of Neurosurgical Societies I-III) before occlusion of the ruptured intracerebral aneurysm, 20% had unfavorable outcome after 1 year. Poor outcome was associated with age, complications resulting from the aSAH and AEs occurring during aneurysm occlusion.

Indexed as

Adverse eventsAneurysmal subarachnoid hemorrhageComplicationsGood gradeUnfavorable outcome

Identifiers

PMID41982319
PMCPMC13075929

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