ArticleFrontiers in pediatrics2026
From acute immune storm to lifelong vascular risk: a paradigm shift in Kawasaki disease as a chronic disease model.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Based on accumulating evidence, this article proposes redefining Kawasaki disease as a chronic condition that begins with an acute immune response and leads to lasting vascular and immune dysfunction. This perspective moves beyond the traditional view of Kawasaki disease as a "self-limited vasculitis," emphasizing that its pathological processes continue long after acute symptoms resolve. The disease follows a continuum involving persistent immune activation, ongoing low-grade inflammation, impaired blood vessel function, and metabolic changes. This chronic disease model explains why patients face accelerated atherosclerosis and higher long-term cardiovascular risk. The article systematically reviews the biology of the disease from its acute to chronic stages, summarizes supporting clinical and imaging evidence, and discusses the implications for lifelong patient management, personalized treatment strategies, and future research across multiple disciplines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.