ArticleFrontiers in oncology2026
Acral melanoma presenting with multiple intussusceptions: a case report and literature review.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Acral melanoma (AM) is a distinct subtype of melanoma unrelated to ultraviolet exposure, and its amelanotic variant presents considerable diagnostic challenges due to its occult clinical manifestations. Here, we report a rare case of amelanotic acral melanoma (AAM) with brain metastasis, initially presenting as multiple small intestinal intussusceptions. A 66-year-old male presented with abdominal pain and intestinal obstruction. Imaging revealed two sites of small bowel intussusception and space-occupying lesions in the brain. Emergency laparoscopic resection of three intestinal tumors was performed, and postoperative pathological examination confirmed metastatic melanoma. Positron emission tomography-computed tomography (PET-CT) suggested a suspicious primary lesion at the distal end of the right first metatarsal. Genetic testing revealed an activating KIT p.L576P mutation. Following multidisciplinary team discussion, the patient received palliative whole-brain radiotherapy combined with oral imatinib targeted therapy. One month after treatment, neurological function improved significantly, and imaging showed marked regression of the brain metastases. Three months post-treatment, follow-up PET-CT revealed no Fluorodeoxyglucose (FDG) uptake at the distal right first metatarsal. This case highlights the following: (1) Metastatic melanoma should be considered in the differential diagnosis of unexplained adult intussusception; (2) PET-CT is of significant value in detecting occult primary lesions; (3) Genetic testing should be performed in patients with acral melanoma to guide targeted therapy; (4) A multidisciplinary integrated diagnosis and treatment model combining local intervention for acute complications with systemic targeted therapy represents an effective strategy for advanced complex cases.
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