ArticleFrontiers in oncology2026
Bovine pericardial patch for preventing air leak after thoracoscopic-assisted pulmonary wedge resection: a retrospective cohort study with predictive modeling.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Thoracoscopic wedge resection has become a standard procedure for pulmonary nodule management, yet postoperative air leak (PAL) remains a prevalent complication. While bovine pericardial patches are established in cardiovascular surgery, their utility in pulmonary resection merits further investigation. This study aimed to assess the efficacy of bovine pericardial patches in reducing PAL after thoracoscopic wedge resection and develop a predictive model for clinical utility. Methods: In this single-center retrospective study (2015-2020), we analyzed 2006 thoracoscopic wedge resections at Fujian Medical University Union Hospital, comparing 319 patch-treated cases with 1,687 controls. Primary outcomes included PAL incidence; while secondary outcomes encompassed drainage duration. Univariate and multivariate logistic regression analyses identified risk factors for PAL, and a nomogram was constructed to predict PAL risk. Results: Baseline characteristics were well-balanced between groups. The bovine pericardial patch group showed a significantly lower PAL incidence (2.8% vs. 13.2%, Conclusion: Bovine pericardial patch application significantly reduces PAL incidence and shortens chest tube drainage duration after thoracoscopic wedge resection. The predictive nomogram helps identify high-risk patients who would benefit most from this intervention, supporting its use as a cost-effective adjunct in pulmonary surgery.
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