Evidence map›Paper›PMID 41982233›Full record

ReviewFrontiers in oncology2026

Empowering photodynamic therapy with artificial intelligence: current trends and future directions.

Avijit Paul, Marvin Xavierselvan, David Aebisher, Tomasz Kubrak, Dorota Bartusik-Aebisher, Srivalleesha Mallidi

Abstract readReview
In one paragraph

Review in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Avijit PaulDepartment of Biomedical Engineering, Tufts University, Medford, MA, United States.
Marvin XavierselvanDepartment of Biomedical Engineering, Tufts University, Medford, MA, United States.
David AebisherDepartment of Photomedicine and Physical Chemistry, Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszów, Poland.
Tomasz KubrakDepartment of Biochemistry and General Chemistry, Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszów, Poland.
Dorota Bartusik-AebisherDepartment of Biochemistry and General Chemistry, Faculty of Medicine, Collegium Medicum, University of Rzeszów, Rzeszów, Poland.
Srivalleesha MallidiDepartment of Biomedical Engineering, Tufts University, Medford, MA, United States.

Funding

Image-guided oxygen enhanced photodynamic therapy with multi-functional nanodroplets to improve head and neck cancer treatment outcomesR01CA266701 · NCI · TUFTS UNIVERSITY MEDFORD · PI Srivalleesha Mallidi · 2022 to 2026
$1.7M
NCI NIH HHS R01 CA266701
6 · The paper itself

Abstract

The evolution of photodynamic therapy (PDT), from ancient photomedicine practices to modern clinical applications, reflects its remarkable versatility in oncology and beyond. PDT relies on the interaction between photosensitizers, light, and tissue oxygen to generate reactive oxygen species that selectively destroy diseased cells. While the therapy has proven effective across various cancers and non-malignant conditions, tailoring treatment to individual patients remains challenging due to patient-specific variations in tissue optical properties, photosensitizer pharmacokinetics, and tumor heterogeneity. The rapid advancement of artificial intelligence (AI), including machine learning and deep learning, offers transformative opportunities to address these challenges through data-driven optimization and personalization. In this review, we examine how AI is being integrated across the PDT pipeline. We analyze AI-driven approaches for photosensitizer development, including quantitative structure-activity relationship modeling, graph neural networks for property prediction, and generative models for

Indexed as

artificial intelligencecancer therapyclinical translationdeep learningexplainable AIphotodynamic therapyphotosensitizer designtreatment optimization

Identifiers

PMID41982233
PMCPMC13071930

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.