ArticleFrontiers in cardiovascular medicine2026
Sustained blood pressure reduction associated with percutaneous auricular vagus nerve stimulation in hypertensive chronic pain patients: a retrospective dual-center analysis.
Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Corrections and comments
- Erratum issued
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Hypertension is a major risk factor for cardiovascular diseases, affecting over 1.28 billion adults worldwide, with nearly 46% remaining undiagnosed or untreated. Auricular vagus nerve stimulation (aVNS) has emerged as a promising non-invasive neuromodulation approach for autonomic regulation, yet its effects on blood pressure (BP) remain underexplored. Objective: The effects of aVNS on blood pressure in chronic pain patients were evaluated, with a specific focus on differential responses by hypertensive status and antihypertensive treatment. Methods: This retrospective dual-center study analyzed the impact of aVNS on BP in 24 chronic pain patients [mean age 48.5 (9.1) years; 75% female], categorized into non-hypertensive ( Results: Over an 8-week treatment period, hypertensive patients exhibited significant reductions in systolic BP [-10.7 (2.9) mmHg, Conclusions: aVNS may be associated with BP reductions in hypertensive patients particularly those not receiving pharmacological treatment, with minimal effects in normotensive individuals. These retrospective findings suggest a potential sustained benefit in patients with comorbid chronic pain and support further investigation through prospective, sham-controlled trials to confirm efficacy and clarify underlying mechanisms.
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