Evidence map›Paper›PMID 41981942›Full record

ReviewJournal of neurochemistry2026

The Role of Loss-of-Function KCNH2 Variants in Cardiac Arrhythmias, Seizures and the Risk of Sudden Unexpected Death in Epilepsy.

Hian M Lee, Xue N Gan, Khaing Phyu Aung, Ian C Forster, Christopher A Reid, Ming S Soh

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of neurochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hian M LeeThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0002-8524-0366
Xue N GanThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.
Khaing Phyu AungThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0003-3744-5321
Ian C ForsterThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0003-3087-9952
Christopher A ReidThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0002-1457-8028
Ming S SohThe Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.ORCID https://orcid.org/0000-0002-5689-2082

Funding

Anonymous philanthropic giftCitizens United for Research in EpilepsyMedical Research Future Fund 2016012National Health and Medical Research Council 2019804
6 · The paper itself

Abstract

Sudden Unexpected Death in Epilepsy (SUDEP) is the leading cause of mortality in patients in epilepsy, yet its underlying mechanisms are poorly understood. Emerging evidence suggests a significant role for genetic factors that influence cardiac function in SUDEP risk, particularly loss-of-function variants in KCNH2, which encodes the K

Indexed as

Arrhythmias, CardiacEpilepsyERG1 Potassium ChannelGenetic VariationLoss of Function MutationSeizuresSudden Unexpected Death in EpilepsyAnimalsGenetic Predisposition to DiseaseHumansRisk FactorsERG1 Potassium ChannelKCNH2 protein, humanbiomarkerscardiac arrhythmiaepilepsygeneticsion channelsKCNH2SUDEP

Identifiers

PMID41981942
PMCPMC13080245

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.