Evidence map›Paper›PMID 41981881›Full record

ArticleChemSusChem2026

Multifactorial Perspective for Greening Solid-Phase Peptide Synthesis: Rigid Polyacrylate Macroporous Resin in Combination with Green Solvents.

Sikabwe Noki, Ashish Kumar, Cheng Zhang, Alesandra Basso, Simona Serban, Xiaokang Kou, Yanjun Li, Anamika Sharma, Beatriz G de la Torre, Fernando Albericio

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ChemSusChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sikabwe NokiPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0000-0003-1112-8256
Ashish KumarPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
Cheng ZhangSunresin New Materials, Xi'an, China.
Alesandra BassoSunresin New Materials, Xi'an, China.
Simona SerbanSunresin New Materials, Xi'an, China.
Xiaokang KouSunresin New Materials, Xi'an, China.
Yanjun LiSunresin New Materials, Xi'an, China.
Anamika SharmaPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.
Beatriz G de la TorrePeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0000-0001-8521-9172
Fernando AlbericioPeptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Durban, South Africa.ORCID https://orcid.org/0000-0002-8946-0462

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Until now, efforts to 'green' solid-phase peptide synthesis (SPPS) have largely focused on identifying a single solvent capable of replacing dimethylformamide, while relying exclusively on polystyrene-based resins. This approach has proven both challenging and limiting. Here, we propose that the most effective strategy for incorporating greener solvents into SPPS is to identify resin solvent combinations that can simultaneously support the two key reactions in peptide synthesis: coupling and Fmoc deprotection. When a relatively rigid resin is used, resin swelling is no longer a critical parameter in SPPS. This, in turn, enables the use of solvents that do not need to swell the resin, greatly expanding the range of greener solvent options that can be considered. This concept is exemplified by a novel polyacrylate-based rigid macroporous resin, which has enabled the SPPS synthesis of small- to medium-sized peptides using EtOAc, TEP, 2-MeTHF, acetone, and MeCN as single solvents.

Indexed as

green solventpolyacrylate macroporous resinSPPSsustainability

Identifiers

PMID41981881
PMCPMC13080234

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.