ArticleHuman gene therapy2026
Monitoring Fetal Somatic Cell Genome Editing
Alice F Tarantal, Michele L Martinez, Lionel Sanz, Charles I Lee, He Yang, Henriette O'Geen, Dennis J Hartigan-O'Connor, David J Segal
Abstract read
In one paragraphArticle in Human gene therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
8 authors.
Michele L MartinezDepartments of Pediatrics, University of California, Davis, California, USA.
Lionel SanzDepartments of Pediatrics, University of California, Davis, California, USA.
Charles I LeeCell Biology and Human Anatomy, University of California, Davis, California, USA.
He YangBiochemistry and Molecular Medicine, University of California, Davis, California, USA.
Henriette O'GeenBiochemistry and Molecular Medicine, University of California, Davis, California, USA.ORCID 0000-0002-5569-7971 Dennis J Hartigan-O'ConnorCalifornia National Primate Research Center, University of California, Davis, California, USA.
David J SegalBiochemistry and Molecular Medicine, University of California, Davis, California, USA.
Funding
National Institute on Aging (NIA) ColonyP51OD011107 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Simon J. Atkinson · 2012 to 2026
$191.5MSCGE Comparative Studies SupplementU42OD027094 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI HARTIGAN-O'CONNOR, DENNIS J., SEGAL, DAVID J · 2019 to 2023
$14.2MPET/CT for Nonhuman Primate ImagingS10RR025063 · NCRR · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TARANTAL, ALICE F · 2011 to 2011
$2.1MminiEXPLORER-II for Total-Body PET Translational ImagingS10OD028713 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TARANTAL, ALICE F · 2020 to 2020
$1.9MInnovative Translational Imaging Technologies to Monitor Genome Edited Cells in VivoUH3EB028910 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SEGAL, DAVID J, TARANTAL, ALICE F · 2021 to 2022
$935kInnovative Translational Imaging Technologies to Monitor Genome Edited Cells in VivoUH2EB028910 · NIBIB · UNIVERSITY OF CALIFORNIA AT DAVIS · PI SEGAL, DAVID J, TARANTAL, ALICE F · 2019 to 2020
$463kUltrasound Imaging for Nonhuman Primate Translational ResearchS10OD016261 · OD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI TARANTAL, ALICE F · 2013 to 2013
$203kNCRR NIH HHS S10 RR025063NIBIB NIH HHS UH2 EB028910NIBIB NIH HHS UH3 EB028910NIH HHS P51 OD011107NIH HHS S10 OD016261NIH HHS S10 OD028713NIH HHS U42 OD027094
6 · The paper itselfAbstract
Translational development of somatic cell genome editing requires monitoring the extent of editing in the body at a given time, the specificity of editing, durability, and the potential for adverse events. A noninvasive approach that can identify edited cells
Indexed as
FetusGene EditingPositron-Emission TomographyAnimalsDependovirusFemaleGenetic VectorsMacaca mulattaPregnancyWhole Body ImagingAAV9fetusin vivo imagingPETrhesus monkeySaCas9
Identifiers
PMID41981831
PMCPMC13180422
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