Trial reportJournal of cosmetic dermatology2026
Improved Skin Quality with a Novel Topical Body Serum: Distal Thighs and Back of Hands.
Trial report in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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Authors and funding
6 authors.
Funding
Abstract
backgroundIntrinsic and extrinsic factors contribute to the loss of dermal extracellular matrix (ECM), which can result in a decline of skin quality and clinical signs of aging skin.
objectiveThis randomized, double-blinded, split-body, vehicle-controlled, 12-week study evaluated the efficacy of a skin body firming serum (BFS) that targets ECM renewal to improve skin quality on the distal thighs and back of hands.
methodsAdults with mild-to-moderate skin crepiness applied either BFS or vehicle twice daily to their assigned treatment side. Clinical investigator assessments, digital imaging, and participant self-assessments were performed. Skin biopsies were taken from a limited number of participants for histologic analysis.
resultsParticipants were divided into 2 groups: treatment on the distal thighs (N = 11) and treatment on the back of hands (N = 12). Significant improvements in distal thigh firmness, texture, crepiness, and fine lines/wrinkles were observed from BFS treatment at weeks 4 and 12 over vehicle treatment and baseline. Firmness and texture on the back of hands significantly improved at weeks 8 and 12 of BFS treatment relative to baseline, with crepiness significantly improving at weeks 2 and 12. Significant improvements were seen in body skin texture (distal thighs), firmness (back of hands), and crepiness (back of hands) at week 12, and fine lines/wrinkles (distal thighs) at week 8, with vehicle treatment in comparison to baseline. Participants reported higher satisfaction with BFS than vehicle through week 12. Exploratory histologic assessments showed induction of collagen and elastic fibers.
conclusionsBFS significantly improved skin quality in both the distal thighs and back of hands, suggesting that BFS enhances body skin quality.
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