Evidence map›Paper›PMID 41981790›Full record

ArticleJournal of food science2026

Antioxidant Activity, Phytochemical Characterization, and In Vitro Antitumor Effects of Foam-Mat Dried Mango (Mangifera indica L.) Pulp.

Lia Igel Sodré, Rosana Bizon Carias, Priscila Borchio, Pedro Paulo Saldanha Coimbra, Ananda da Silva Antonio, Henrique Marcelo Gualberto Pereira, Maria Eduarda Flores, Carlos Eduardo Faria, Jorge da Silva Pinho, Vanessa Naciuk Castelo-Branco and 3 more

Abstract read
In one paragraph

Article in Journal of food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lia Igel SodréPostgraduate Program in Nutritional Sciences, Federal Fluminense University, Niterói, RJ, Brazil.ORCID https://orcid.org/0000-0003-1126-5357
Rosana Bizon CariasLaboratory of Regenerative Medicine, Arthur Sá Earp Neto University Center/Faculty of Medicine of Petrópolis (UNIFASE/FMP), Petrópolis, RJ, Brazil.
Priscila BorchioLaboratory of Regenerative Medicine, Arthur Sá Earp Neto University Center/Faculty of Medicine of Petrópolis (UNIFASE/FMP), Petrópolis, RJ, Brazil.
Pedro Paulo Saldanha CoimbraLaboratory of Environmental Mutagenicity, Department of Biophysics and Biometry, State University of Rio de Janeiro, RJ, Brazil.
Ananda da Silva AntonioLaboratory for Technological Development Support, Institute of Chemistry (LADETEC), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Henrique Marcelo Gualberto PereiraLaboratory for Technological Development Support, Institute of Chemistry (LADETEC), Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Maria Eduarda FloresIntegrated Center for Food and Nutrition (CIAN), Federal Fluminense University, Niterói, RJ, Brazil.
Carlos Eduardo FariaIntegrated Center for Food and Nutrition (CIAN), Federal Fluminense University, Niterói, RJ, Brazil.
Jorge da Silva PinhoFood Biotechnology Laboratory (LABIOTEC), Faculty of Pharmacy, Federal Fluminense University, Niterói, RJ, Brazil.
Vanessa Naciuk Castelo-BrancoFood Biotechnology Laboratory (LABIOTEC), Faculty of Pharmacy, Federal Fluminense University, Niterói, RJ, Brazil.ORCID https://orcid.org/0000-0002-0776-9299
Francine Albernaz LoboDepartment of Food Science, Federal University of the State of Rio de Janeiro, Rio de Janeiro, Brazil.
Valdir Florêncio da Veiga-JuniorDepartment of Chemical Engineering, Military Engineering Institute (IME), Rio de Janeiro, Brazil.
Anderson Junger TeodoroIntegrated Center for Food and Nutrition (CIAN), Federal Fluminense University, Niterói, RJ, Brazil.ORCID https://orcid.org/0000-0002-0949-9528

Funding

CAPES
6 · The paper itself

Abstract

This study investigated the antioxidant, antiproliferative, and antitumor effects of dried mango pulp (DMP) on human colorectal adenocarcinoma (Caco-2) and human osteosarcoma (MG63) cell lines. The mango pulp was dehydrated using the foam-mat drying method, and its bioactive compounds were identified by HPLC, UHPLC-MS, and the Folin-Ciocalteu assay, in addition to an in vitro evaluation of antioxidant capacity. DMP significantly decreased cell viability in a dose- and time-dependent manner, with maximal inhibition at 5 mg/mL after 96 h (78.3% for Caco-2; 72.69% for MG63; p < 0.01-0.001). In addition, DMP increased apoptosis rates (p < 0.05) and reduced colony formation (p < 0.05) of both cell lines. These results suggest that DMP is a rich source of phenolic and carotenoid compounds with remarkable antioxidant activity and antitumor potential, possibly mediated by apoptosis pathways. PRACTICAL APPLICATIONS: Dried mango pulp contains natural compounds with strong antioxidant activity and the ability to slow cell growth and promote cell death in laboratory models of colorectal and bone cancer. These findings suggest it could be explored in the future as a supportive ingredient in health-focused foods or supplements.

Indexed as

Antineoplastic Agents, PhytogenicAntioxidantsFruitMangiferaPhytochemicalsPlant ExtractsApoptosisCaco-2 CellsCarotenoidsCell Line, TumorCell ProliferationCell SurvivalChromatography, High Pressure LiquidHumansPhenolsAntineoplastic Agents, PhytogenicAntioxidantsCarotenoidsPhenolsPhytochemicalsPlant Extracts

Identifiers

PMID41981790
PMCPMC13080074

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.