ArticlePhysiological reports2026
Circulating elastin crosslinking desmosines are associated with arterial wall degradation in older adults with atherosclerosis.
Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Tissue Structure as a Primary Factor Influencing Vascular Sealing: Results of an Ex Vivo Study on Porcine Carotid Arteries.Bioengineering (Basel, Switzerland) · 2026Article
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8 authors.
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Abstract
Elastin, an extracellular matrix component that contributes to vascular integrity, is progressively degraded during vascular injury including atherosclerosis. We assessed circulating desmosine (DES) and isodesmosine (IDES), elastin-specific crosslinking amino acids, as indicators of arterial elastin degradation by isotope-dilution liquid chromatography-tandem mass spectrometry. Thirty-eight patients with atherosclerotic ischemic heart disease (IHD) and 30 age- and sex-matched healthy controls were enrolled. Plasma concentrations of both DES and IDES were significantly higher in IHD patients than in controls. The area under the receiver operating characteristic curve for total desmosines (DES + IDES) was 0.763. Multivariable analysis revealed that traditional risk factors for atherosclerosis were not significantly associated with plasma concentrations of desmosines. These findings suggest that circulating desmosines reflect arterial wall degeneration in atherosclerosis and are independent of traditional risk factors.
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