ArticleBMC women's health2026
Association of exposure to organophosphate pesticides with reproductive lifespan.
Article in BMC women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOrganophosphate pesticides (OPs) have been found to have reproductive toxicity with overt endocrine disruption potential, yet the relationships between OPs with reproductive lifespan remain unexplored.
objectiveWe aimed to investigate associations between urinary OP concentrations with reproductive lifespan.
methodThis study included 1,356 postmenopausal women who participated in the National Health and Nutrition Examination Survey from 1999 to 2018 to evaluate the relationship between OP exposure and reproductive lifespan. Urine was analysed using gas chromatography coupled with mass spectrometry for concentrations of six dialkyl phosphate (DAP) metabolites of OPs.
resultMultivariate linear regression and Bayesian kernel machine regression (BKMR) models revealed that total urinary DAP metabolite concentrations (β = 0.10, 95% CI: 0.03–0.17, p = 0.006) were positively associated with age at menopause. Urinary dimethyl phosphate (DMP) concentration was positively associated with age at menopause (β = 0.67, 95% CI: 0.30–1.03, p = 0.001) and reproductive lifespan (β = 0.64, 95% CI: 0.26–1.02, p = 0.001). Furthermore, BKMR and weighted quantile sum models identified DMP as the primary risk contributor amongst the six detected DAP metabolites (weight = 0.573 for age at menopause and weight = 0.634 for reproductive lifespan).
conclusionFor the mixed analysis, the overall exposure to DAP metabolites was associated with delayed age at menopause. For the individual analysis, DMP exposure was associated with delayed age at menopause and longer reproductive lifespan, and DMP was identified as the major risk factor amongst the six detected DAP metabolites. Future research should prioritise DMP to further elucidate impacts of OPs exposure on female reproductive health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.